Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013.
The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5722308?pdf=render |
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| author | Jose Reyes Canche-Pech Laura Conde-Ferraez Marylin Puerto-Solis Refugio Gonzalez-Losa Pilar Granja-Pérez Salha Villanueva-Jorge Maria Chan-Gasca Jesus Gómez-Carballo Luisa López-Ochoa Bertha Jiménez-Delgadillo Iram Rodríguez-Sánchez Jorge Ramírez-Prado Guadalupe Ayora-Talavera |
| author_facet | Jose Reyes Canche-Pech Laura Conde-Ferraez Marylin Puerto-Solis Refugio Gonzalez-Losa Pilar Granja-Pérez Salha Villanueva-Jorge Maria Chan-Gasca Jesus Gómez-Carballo Luisa López-Ochoa Bertha Jiménez-Delgadillo Iram Rodríguez-Sánchez Jorge Ramírez-Prado Guadalupe Ayora-Talavera |
| author_sort | Jose Reyes Canche-Pech |
| collection | DOAJ |
| description | The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N1)pdm09 virus throughout the year. We have characterized the molecular composition of the Hemagglutinin (HA) and Neuraminidase (NA) genes of the A(H1N1)pdm09 virus from both epidemic seasons, emphasizing the genetic characteristics of viruses isolated from Yucatan in Southern Mexico. The molecular analysis of viruses from the 2012 revealed that all viruses from Mexico were predominantly grouped in clade 7. Strikingly, the molecular characterization of viruses from 2013 revealed that viruses circulating in Yucatan were genetically different to viruses from other regions of Mexico. In fact, we identified the occurrence of two genetic variants containing relevant mutations at both the HA and NA surface antigens. There was a difference on the temporal circulation of each genetic variant, viruses containing the mutations HA-A141T / NA-N341S were detected in May, June and July; whereas viruses containing the mutations HA-S162I / NA-L206S circulated in August and September. We discuss the significance of these novel genetic changes. |
| first_indexed | 2024-12-21T12:02:38Z |
| format | Article |
| id | doaj.art-589d1362b0964317aa919215b34311c3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T12:02:38Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-589d1362b0964317aa919215b34311c32022-12-21T19:04:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011212e018936310.1371/journal.pone.0189363Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013.Jose Reyes Canche-PechLaura Conde-FerraezMarylin Puerto-SolisRefugio Gonzalez-LosaPilar Granja-PérezSalha Villanueva-JorgeMaria Chan-GascaJesus Gómez-CarballoLuisa López-OchoaBertha Jiménez-DelgadilloIram Rodríguez-SánchezJorge Ramírez-PradoGuadalupe Ayora-TalaveraThe 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N1)pdm09 virus throughout the year. We have characterized the molecular composition of the Hemagglutinin (HA) and Neuraminidase (NA) genes of the A(H1N1)pdm09 virus from both epidemic seasons, emphasizing the genetic characteristics of viruses isolated from Yucatan in Southern Mexico. The molecular analysis of viruses from the 2012 revealed that all viruses from Mexico were predominantly grouped in clade 7. Strikingly, the molecular characterization of viruses from 2013 revealed that viruses circulating in Yucatan were genetically different to viruses from other regions of Mexico. In fact, we identified the occurrence of two genetic variants containing relevant mutations at both the HA and NA surface antigens. There was a difference on the temporal circulation of each genetic variant, viruses containing the mutations HA-A141T / NA-N341S were detected in May, June and July; whereas viruses containing the mutations HA-S162I / NA-L206S circulated in August and September. We discuss the significance of these novel genetic changes.http://europepmc.org/articles/PMC5722308?pdf=render |
| spellingShingle | Jose Reyes Canche-Pech Laura Conde-Ferraez Marylin Puerto-Solis Refugio Gonzalez-Losa Pilar Granja-Pérez Salha Villanueva-Jorge Maria Chan-Gasca Jesus Gómez-Carballo Luisa López-Ochoa Bertha Jiménez-Delgadillo Iram Rodríguez-Sánchez Jorge Ramírez-Prado Guadalupe Ayora-Talavera Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. PLoS ONE |
| title | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. |
| title_full | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. |
| title_fullStr | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. |
| title_full_unstemmed | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. |
| title_short | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. |
| title_sort | temporal distribution and genetic variants in influenza a h1n1 pdm09 virus circulating in mexico seasons 2012 and 2013 |
| url | http://europepmc.org/articles/PMC5722308?pdf=render |
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