Nomograms of human hippocampal volume shifted by polygenic scores

Nomograms of human hippocampal volume shifted by polygenic scores

Nomograms are important clinical tools applied widely in both developing and aging populations. They are generally constructed as normative models identifying cases as outliers to a distribution of healthy controls. Currently used normative models do not account for genetic heterogeneity. Hippocampa...

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Bibliographic Details
Main Authors: Mohammed Janahi, Leon Aksman, Jonathan M Schott, Younes Mokrab, Andre Altmann, On behalf of for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
polygenic score
neuroimaging
genetics
normative modelling
bioinformatics
Online Access:https://elifesciences.org/articles/78232

Internet

https://elifesciences.org/articles/78232

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