The saga of dyssynchrony imaging: Are we getting to the point
Cardiac resynchronisation therapy (CRT) has an established role in the management of patients with heart failure, reduced left ventricular ejection fraction (LVEF < 35%) and widened QRS (>130 msec). Despite the complex pathophysiology of left ventricular (LV) dyssynchrony and the incre...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1111538/full |
| _version_ | 1827975595870388224 |
|---|---|
| author | Elena Galli Vincent Galand Virginie Le Rolle Marion Taconne Adrien Al Wazzan Alfredo Hernandez Christophe Leclercq Erwan Donal |
| author_facet | Elena Galli Vincent Galand Virginie Le Rolle Marion Taconne Adrien Al Wazzan Alfredo Hernandez Christophe Leclercq Erwan Donal |
| author_sort | Elena Galli |
| collection | DOAJ |
| description | Cardiac resynchronisation therapy (CRT) has an established role in the management of patients with heart failure, reduced left ventricular ejection fraction (LVEF < 35%) and widened QRS (>130 msec). Despite the complex pathophysiology of left ventricular (LV) dyssynchrony and the increasing evidence supporting the identification of specific electromechanical substrates that are associated with a higher probability of CRT response, the assessment of LVEF is the only imaging-derived parameter used for the selection of CRT candidates.This review aims to (1) provide an overview of the evolution of cardiac imaging for the assessment of LV dyssynchrony and its role in the selection of patients undergoing CRT; (2) highlight the main pitfalls and advantages of the application of cardiac imaging for the assessment of LV dyssynchrony; (3) provide some perspectives for clinical application and future research in this field.Conclusionthe road for a more individualized approach to resynchronization therapy delivery is open and imaging might provide important input beyond the assessment of LVEF. |
| first_indexed | 2024-04-09T20:14:12Z |
| format | Article |
| id | doaj.art-589e4cfb7e3e4e44b9900de2c14ef89b |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T20:14:12Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-589e4cfb7e3e4e44b9900de2c14ef89b2023-03-31T12:02:03ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11115381111538The saga of dyssynchrony imaging: Are we getting to the pointElena GalliVincent GalandVirginie Le RolleMarion TaconneAdrien Al WazzanAlfredo HernandezChristophe LeclercqErwan DonalCardiac resynchronisation therapy (CRT) has an established role in the management of patients with heart failure, reduced left ventricular ejection fraction (LVEF < 35%) and widened QRS (>130 msec). Despite the complex pathophysiology of left ventricular (LV) dyssynchrony and the increasing evidence supporting the identification of specific electromechanical substrates that are associated with a higher probability of CRT response, the assessment of LVEF is the only imaging-derived parameter used for the selection of CRT candidates.This review aims to (1) provide an overview of the evolution of cardiac imaging for the assessment of LV dyssynchrony and its role in the selection of patients undergoing CRT; (2) highlight the main pitfalls and advantages of the application of cardiac imaging for the assessment of LV dyssynchrony; (3) provide some perspectives for clinical application and future research in this field.Conclusionthe road for a more individualized approach to resynchronization therapy delivery is open and imaging might provide important input beyond the assessment of LVEF.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1111538/fullcardiac imagingcardiac resynchronization therapyleft ventricular dyssynchronyheart failureleft ventricular remodelling |
| spellingShingle | Elena Galli Vincent Galand Virginie Le Rolle Marion Taconne Adrien Al Wazzan Alfredo Hernandez Christophe Leclercq Erwan Donal The saga of dyssynchrony imaging: Are we getting to the point Frontiers in Cardiovascular Medicine cardiac imaging cardiac resynchronization therapy left ventricular dyssynchrony heart failure left ventricular remodelling |
| title | The saga of dyssynchrony imaging: Are we getting to the point |
| title_full | The saga of dyssynchrony imaging: Are we getting to the point |
| title_fullStr | The saga of dyssynchrony imaging: Are we getting to the point |
| title_full_unstemmed | The saga of dyssynchrony imaging: Are we getting to the point |
| title_short | The saga of dyssynchrony imaging: Are we getting to the point |
| title_sort | saga of dyssynchrony imaging are we getting to the point |
| topic | cardiac imaging cardiac resynchronization therapy left ventricular dyssynchrony heart failure left ventricular remodelling |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1111538/full |
| work_keys_str_mv | AT elenagalli thesagaofdyssynchronyimagingarewegettingtothepoint AT vincentgaland thesagaofdyssynchronyimagingarewegettingtothepoint AT virginielerolle thesagaofdyssynchronyimagingarewegettingtothepoint AT mariontaconne thesagaofdyssynchronyimagingarewegettingtothepoint AT adrienalwazzan thesagaofdyssynchronyimagingarewegettingtothepoint AT alfredohernandez thesagaofdyssynchronyimagingarewegettingtothepoint AT christopheleclercq thesagaofdyssynchronyimagingarewegettingtothepoint AT erwandonal thesagaofdyssynchronyimagingarewegettingtothepoint AT elenagalli sagaofdyssynchronyimagingarewegettingtothepoint AT vincentgaland sagaofdyssynchronyimagingarewegettingtothepoint AT virginielerolle sagaofdyssynchronyimagingarewegettingtothepoint AT mariontaconne sagaofdyssynchronyimagingarewegettingtothepoint AT adrienalwazzan sagaofdyssynchronyimagingarewegettingtothepoint AT alfredohernandez sagaofdyssynchronyimagingarewegettingtothepoint AT christopheleclercq sagaofdyssynchronyimagingarewegettingtothepoint AT erwandonal sagaofdyssynchronyimagingarewegettingtothepoint |