Fluctuations of testosterone in acute coronary syndrome
<p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;">...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sri Lanka College of Endocrinologists
2013-05-01
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| Series: | Sri Lanka Journal of Diabetes Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://sjdem.sljol.info/articles/5470 |
| _version_ | 1819089680335896576 |
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| author | CM Wickramatilake MR Mohideen C Pathirana |
| author_facet | CM Wickramatilake MR Mohideen C Pathirana |
| author_sort | CM Wickramatilake |
| collection | DOAJ |
| description | <p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;"><em><strong>Objective: </strong></em></span></span><span style="color: #231f20;"><span style="font-size: x-small;">Fluctuations of serum testosterone after acute coronary syndrome (ACS) are infrequently reported. This study was done to determine the optimal time point for blood sampling for testosterone levels after ACS and to observe the trend of serial estimates of testosterone up to 12 weeks (84 days) following the acute event.</span></span></span></span></span></p> <p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;"><em><strong>Methods: </strong></em></span></span><span style="color: #231f20;"><span style="font-size: x-small;">Eight patients with ACS; five with ST-segment-elevated-myocardial infarction (STEMI) and three with unstable angina (UA) were included. Five blood samples were taken; on admission (day one), day three, day 24 and day 84 (12 weeks) later. Serum total testosterone (TT) was estimated by radioimmunoassay.</span></span></span></span></span></p> <p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;"><em><strong>Results: </strong></em></span></span><span style="color: #231f20;"><span style="font-size: x-small;">Mean age was 53±5 years. Mean serum TT level on admission (day one) was 3.60±1.74 ng/mL and on day three, it was 3.98±2.04 ng/mL. The values rose to 5.09±2.24 ng/mL on day five and peaked to 6.17±2.98 ng/mL at 24 days after. Thereafter, the TT levels declined to a mean level of 4.14±2.06 ng/ mL by 12 weeks, similar to that observed in the first three days after the acute episode. No significant difference was observed between the mean TT levels on admission, day three and at day 84 (p = 0.407, p = 0.628).</span></span></span></span></span></p> <p style="margin-bottom: 0in;"><span style="color: #231f20;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><em><strong>Conclusion: </strong></em></span></span></span><span style="color: #231f20;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;">Serum testosterone fluctuates after ACS. The optimal time to obtain blood for total testosterone level that represents baseline appears to be within the first three days from the onset of the event.</span></span></span></p> <p><span style="color: #231f20;"><span style="font-family: Times New Roman,serif;"><span style="font-size: x-small;"><em>Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2013; </em></span></span></span><span style="color: #231f20;"><span style="font-family: Times New Roman,serif;"><span style="font-size: x-small;"><em><strong>3</strong></em></span></span></span><span style="color: #231f20;"><span style="font-family: Times New Roman,serif;"><span style="font-size: x-small;"><em>: 8-11</em></span></span></span></p><p>DOI: <a href="http://dx.doi.org/10.4038/sjdem.v3i1.5470">http://dx.doi.org/10.4038/sjdem.v3i1.5470</a></p><a href="http://dx.doi.org/"></a><p style="margin-bottom: 0in;"> </p> |
| first_indexed | 2024-12-21T22:11:47Z |
| format | Article |
| id | doaj.art-589fb66210a44666b3c2f49b2bcd48d5 |
| institution | Directory Open Access Journal |
| issn | 2012-998X |
| language | English |
| last_indexed | 2024-12-21T22:11:47Z |
| publishDate | 2013-05-01 |
| publisher | Sri Lanka College of Endocrinologists |
| record_format | Article |
| series | Sri Lanka Journal of Diabetes Endocrinology and Metabolism |
| spelling | doaj.art-589fb66210a44666b3c2f49b2bcd48d52022-12-21T18:48:33ZengSri Lanka College of EndocrinologistsSri Lanka Journal of Diabetes Endocrinology and Metabolism2012-998X2013-05-013181110.4038/sjdem.v3i1.54704374Fluctuations of testosterone in acute coronary syndromeCM Wickramatilake0MR Mohideen1C Pathirana2University of RuhunaUniversity of RuhunaUniversity of Ruhuna<p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;"><em><strong>Objective: </strong></em></span></span><span style="color: #231f20;"><span style="font-size: x-small;">Fluctuations of serum testosterone after acute coronary syndrome (ACS) are infrequently reported. This study was done to determine the optimal time point for blood sampling for testosterone levels after ACS and to observe the trend of serial estimates of testosterone up to 12 weeks (84 days) following the acute event.</span></span></span></span></span></p> <p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;"><em><strong>Methods: </strong></em></span></span><span style="color: #231f20;"><span style="font-size: x-small;">Eight patients with ACS; five with ST-segment-elevated-myocardial infarction (STEMI) and three with unstable angina (UA) were included. Five blood samples were taken; on admission (day one), day three, day 24 and day 84 (12 weeks) later. Serum total testosterone (TT) was estimated by radioimmunoassay.</span></span></span></span></span></p> <p style="margin-bottom: 0in;"><span style="color: #000000;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><span style="color: #231f20;"><span style="font-size: x-small;"><em><strong>Results: </strong></em></span></span><span style="color: #231f20;"><span style="font-size: x-small;">Mean age was 53±5 years. Mean serum TT level on admission (day one) was 3.60±1.74 ng/mL and on day three, it was 3.98±2.04 ng/mL. The values rose to 5.09±2.24 ng/mL on day five and peaked to 6.17±2.98 ng/mL at 24 days after. Thereafter, the TT levels declined to a mean level of 4.14±2.06 ng/ mL by 12 weeks, similar to that observed in the first three days after the acute episode. No significant difference was observed between the mean TT levels on admission, day three and at day 84 (p = 0.407, p = 0.628).</span></span></span></span></span></p> <p style="margin-bottom: 0in;"><span style="color: #231f20;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;"><em><strong>Conclusion: </strong></em></span></span></span><span style="color: #231f20;"><span style="font-family: Arial,sans-serif;"><span style="font-size: x-small;">Serum testosterone fluctuates after ACS. The optimal time to obtain blood for total testosterone level that represents baseline appears to be within the first three days from the onset of the event.</span></span></span></p> <p><span style="color: #231f20;"><span style="font-family: Times New Roman,serif;"><span style="font-size: x-small;"><em>Sri Lanka Journal of Diabetes, Endocrinology and Metabolism 2013; </em></span></span></span><span style="color: #231f20;"><span style="font-family: Times New Roman,serif;"><span style="font-size: x-small;"><em><strong>3</strong></em></span></span></span><span style="color: #231f20;"><span style="font-family: Times New Roman,serif;"><span style="font-size: x-small;"><em>: 8-11</em></span></span></span></p><p>DOI: <a href="http://dx.doi.org/10.4038/sjdem.v3i1.5470">http://dx.doi.org/10.4038/sjdem.v3i1.5470</a></p><a href="http://dx.doi.org/"></a><p style="margin-bottom: 0in;"> </p>https://sjdem.sljol.info/articles/5470testosteroneacute stress responseacute coronary syndrome |
| spellingShingle | CM Wickramatilake MR Mohideen C Pathirana Fluctuations of testosterone in acute coronary syndrome Sri Lanka Journal of Diabetes Endocrinology and Metabolism testosterone acute stress response acute coronary syndrome |
| title | Fluctuations of testosterone in acute coronary syndrome |
| title_full | Fluctuations of testosterone in acute coronary syndrome |
| title_fullStr | Fluctuations of testosterone in acute coronary syndrome |
| title_full_unstemmed | Fluctuations of testosterone in acute coronary syndrome |
| title_short | Fluctuations of testosterone in acute coronary syndrome |
| title_sort | fluctuations of testosterone in acute coronary syndrome |
| topic | testosterone acute stress response acute coronary syndrome |
| url | https://sjdem.sljol.info/articles/5470 |
| work_keys_str_mv | AT cmwickramatilake fluctuationsoftestosteroneinacutecoronarysyndrome AT mrmohideen fluctuationsoftestosteroneinacutecoronarysyndrome AT cpathirana fluctuationsoftestosteroneinacutecoronarysyndrome |