Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases
Introduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10–15% of crescentic glomerulonephritis and is associated with poor outcome. In this study, we have elaborated on the clinical details, morphological fea...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=2;spage=226;epage=229;aulast=Vavilapalli |
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| author | Srinivasrao Vavilapalli Nishika Madireddy Megha S Uppin Karthik Kalidindi Swarnalatha Gudithi Gangadhar Taduri Sree Bhushan Raju |
| author_facet | Srinivasrao Vavilapalli Nishika Madireddy Megha S Uppin Karthik Kalidindi Swarnalatha Gudithi Gangadhar Taduri Sree Bhushan Raju |
| author_sort | Srinivasrao Vavilapalli |
| collection | DOAJ |
| description | Introduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10–15% of crescentic glomerulonephritis and is associated with poor outcome. In this study, we have elaborated on the clinical details, morphological features, and outcome of anti-GBM glomerulonephritis. Materials and Methods: All the consecutive biopsy-proven cases of anti-GBM glomerulonephritis over a period of 4½ years were analyzed, retrospectively. Results: Sixteen cases were diagnosed as anti-GBM glomerulonephritis during the study period. Twelve patients presented with rapidly progressive renal failure of which four patients required hemodialysis at the time of presentation. Goodpasture's syndrome was noted in two patients. Thirteen cases were positive for circulating anti-GBM antibodies and two patients showed double positivity for both anti-GBM antibodies and ANCA. Fifteen biopsies revealed crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane in all the 16 cases. Conclusion: Renal biopsy analysis is important in the diagnosis of Anti GBM nephritis. Morphology is an important predictor of disease progression. |
| first_indexed | 2024-12-13T11:33:41Z |
| format | Article |
| id | doaj.art-58a0b33053664ddf91b0eecb537deb45 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-13T11:33:41Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-58a0b33053664ddf91b0eecb537deb452022-12-21T23:47:51ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292020-01-0163222622910.4103/IJPM.IJPM_712_18Anti-glomerular basement membrane disease: A clinicomorphological study of 16 casesSrinivasrao VavilapalliNishika MadireddyMegha S UppinKarthik KalidindiSwarnalatha GudithiGangadhar TaduriSree Bhushan RajuIntroduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10–15% of crescentic glomerulonephritis and is associated with poor outcome. In this study, we have elaborated on the clinical details, morphological features, and outcome of anti-GBM glomerulonephritis. Materials and Methods: All the consecutive biopsy-proven cases of anti-GBM glomerulonephritis over a period of 4½ years were analyzed, retrospectively. Results: Sixteen cases were diagnosed as anti-GBM glomerulonephritis during the study period. Twelve patients presented with rapidly progressive renal failure of which four patients required hemodialysis at the time of presentation. Goodpasture's syndrome was noted in two patients. Thirteen cases were positive for circulating anti-GBM antibodies and two patients showed double positivity for both anti-GBM antibodies and ANCA. Fifteen biopsies revealed crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane in all the 16 cases. Conclusion: Renal biopsy analysis is important in the diagnosis of Anti GBM nephritis. Morphology is an important predictor of disease progression.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=2;spage=226;epage=229;aulast=Vavilapallianti gbm antibody diseasecrescentic glomerulonephritisrapidly progressive glomerulonephritis |
| spellingShingle | Srinivasrao Vavilapalli Nishika Madireddy Megha S Uppin Karthik Kalidindi Swarnalatha Gudithi Gangadhar Taduri Sree Bhushan Raju Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases Indian Journal of Pathology and Microbiology anti gbm antibody disease crescentic glomerulonephritis rapidly progressive glomerulonephritis |
| title | Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases |
| title_full | Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases |
| title_fullStr | Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases |
| title_full_unstemmed | Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases |
| title_short | Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases |
| title_sort | anti glomerular basement membrane disease a clinicomorphological study of 16 cases |
| topic | anti gbm antibody disease crescentic glomerulonephritis rapidly progressive glomerulonephritis |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2020;volume=63;issue=2;spage=226;epage=229;aulast=Vavilapalli |
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