Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications
Abstract Oxidative stress is an imbalance between the body’s reactive oxygen species and antioxidant defense mechanisms. Oxidative stress is involved in the development of several cardiovascular diseases, such as pulmonary hypertension, atherosclerosis, and diabetes mellitus. A growing number of stu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-023-00577-1 |
| _version_ | 1797355573097791488 |
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| author | Jingchao Yang Jinzhu Xu Shuanglan Xu Zeqin Fan Chenshao Zhu Jianyuan Wan Jiao Yang Xiqian Xing |
| author_facet | Jingchao Yang Jinzhu Xu Shuanglan Xu Zeqin Fan Chenshao Zhu Jianyuan Wan Jiao Yang Xiqian Xing |
| author_sort | Jingchao Yang |
| collection | DOAJ |
| description | Abstract Oxidative stress is an imbalance between the body’s reactive oxygen species and antioxidant defense mechanisms. Oxidative stress is involved in the development of several cardiovascular diseases, such as pulmonary hypertension, atherosclerosis, and diabetes mellitus. A growing number of studies have suggested the potential role of oxidative stress in the pathogenesis of pulmonary embolism. Biomarkers of oxidative stress in pulmonary embolism have also been explored, such as matrix metalloproteinases, asymmetric dimethylarginine, and neutrophil/lymphocyte ratio. Here, we comprehensively summarize some oxidative stress mechanisms and biomarkers in the development of acute pulmonary embolism and summarize related treatments based on antioxidant stress to explore effective treatment strategies for acute pulmonary embolism. |
| first_indexed | 2024-03-08T14:13:06Z |
| format | Article |
| id | doaj.art-58a0e94ca52044d0b0268f8a12d8f5ed |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-03-08T14:13:06Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-58a0e94ca52044d0b0268f8a12d8f5ed2024-01-14T12:33:14ZengBMCThrombosis Journal1477-95602024-01-0122111310.1186/s12959-023-00577-1Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implicationsJingchao Yang0Jinzhu Xu1Shuanglan Xu2Zeqin Fan3Chenshao Zhu4Jianyuan Wan5Jiao Yang6Xiqian Xing7Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Yuxi Municipal Hospital of T.C. MDepartment of Pulmonary and Critical Care Medicine, Affiliated Hospital of Yunnan UniversityDepartment of Pulmonary and Critical Care Medicine, Affiliated Hospital of Yunnan UniversityDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical UniversityDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical UniversityDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Affiliated Hospital of Yunnan UniversityAbstract Oxidative stress is an imbalance between the body’s reactive oxygen species and antioxidant defense mechanisms. Oxidative stress is involved in the development of several cardiovascular diseases, such as pulmonary hypertension, atherosclerosis, and diabetes mellitus. A growing number of studies have suggested the potential role of oxidative stress in the pathogenesis of pulmonary embolism. Biomarkers of oxidative stress in pulmonary embolism have also been explored, such as matrix metalloproteinases, asymmetric dimethylarginine, and neutrophil/lymphocyte ratio. Here, we comprehensively summarize some oxidative stress mechanisms and biomarkers in the development of acute pulmonary embolism and summarize related treatments based on antioxidant stress to explore effective treatment strategies for acute pulmonary embolism.https://doi.org/10.1186/s12959-023-00577-1Oxidative stressAcute Pulmonary EmbolismEndothelial cellsReactive oxygen speciesAntioxidants |
| spellingShingle | Jingchao Yang Jinzhu Xu Shuanglan Xu Zeqin Fan Chenshao Zhu Jianyuan Wan Jiao Yang Xiqian Xing Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications Thrombosis Journal Oxidative stress Acute Pulmonary Embolism Endothelial cells Reactive oxygen species Antioxidants |
| title | Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications |
| title_full | Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications |
| title_fullStr | Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications |
| title_full_unstemmed | Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications |
| title_short | Oxidative stress in acute pulmonary embolism: emerging roles and therapeutic implications |
| title_sort | oxidative stress in acute pulmonary embolism emerging roles and therapeutic implications |
| topic | Oxidative stress Acute Pulmonary Embolism Endothelial cells Reactive oxygen species Antioxidants |
| url | https://doi.org/10.1186/s12959-023-00577-1 |
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