Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association
With emergent Sars-Cov-2, a highly transmissive virus that caused millions of deaths worldwide, the development of vaccines became urgent to combat COVID-19. Although rare, important adverse effects had been described in a hypothetical scenario of immune system overstimulation or overreaction. Stil...
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| Format: | Article |
| Language: | English |
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University of São Paulo
2022-11-01
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| Series: | Autopsy and Case Reports |
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| Online Access: | https://www.revistas.usp.br/autopsy/article/view/204212 |
| _version_ | 1798023519818219520 |
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| author | Laíssa Fiorotti Albertino Isac Ribeiro Moulaz Tammer Ferreira Zogheib Martina Zanotti Carneiro Valentim Ketty Lysie Libardi Lira Machado |
| author_facet | Laíssa Fiorotti Albertino Isac Ribeiro Moulaz Tammer Ferreira Zogheib Martina Zanotti Carneiro Valentim Ketty Lysie Libardi Lira Machado |
| author_sort | Laíssa Fiorotti Albertino |
| collection | DOAJ |
| description |
With emergent Sars-Cov-2, a highly transmissive virus that caused millions of deaths worldwide, the development of vaccines became urgent to combat COVID-19. Although rare, important adverse effects had been described in a hypothetical scenario of immune system overstimulation or overreaction. Still’s disease is a rare inflammatory syndrome of unknown etiology. It manifests as a cytokine storm, mainly IL-18 and IL-1β, and presents itself with fever spikes, joint pain, maculopapular evanescent salmon-pink skin rash, and sore throat, among other symptoms. Here, we report a case of a 44-year-old healthy male who developed adult-onset Still’s disease (AOSD) with atypical symptoms after both doses of ChAdOx1 nCoV-19 vaccine with 3 months of dose interval. The medical team suspected Still's disease and started prednisone 1 mg/kg (40mg). The next day the patient showed a marked improvement in articular and chest pains and had no other fever episodes. Therefore, he was discharged to continue the treatment in outpatient care. On the six-month follow-up, the patient was free of complaints, and the progressive corticoid withdrawal plan was already finished.
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| first_indexed | 2024-04-11T17:48:43Z |
| format | Article |
| id | doaj.art-58a1c75df0644a59b41b77cb5646992b |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-04-11T17:48:43Z |
| publishDate | 2022-11-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-58a1c75df0644a59b41b77cb5646992b2022-12-22T04:11:13ZengUniversity of São PauloAutopsy and Case Reports2236-19602022-11-0112Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible associationLaíssa Fiorotti Albertino0Isac Ribeiro Moulaz1Tammer Ferreira Zogheib2Martina Zanotti Carneiro Valentim3Ketty Lysie Libardi Lira Machado4Universidade Federal do Espírito Santo (UFES), Medical School, Vitória, ES, BrasilUniversidade Federal do Espírito Santo (UFES), Medical School, Vitória, ES, BrasilHospital Evangélico de Vila Velha, Department of Internal Medicine, Vila Velha, ES, BrasilVitoria Apart Hospital, Department of Infectology, Vitoria, ES, BrasilUniversidade Federal do Espírito Santo (UFES), Department of Rheumatology, Internal Medicine, Vitória, ES, Brasil With emergent Sars-Cov-2, a highly transmissive virus that caused millions of deaths worldwide, the development of vaccines became urgent to combat COVID-19. Although rare, important adverse effects had been described in a hypothetical scenario of immune system overstimulation or overreaction. Still’s disease is a rare inflammatory syndrome of unknown etiology. It manifests as a cytokine storm, mainly IL-18 and IL-1β, and presents itself with fever spikes, joint pain, maculopapular evanescent salmon-pink skin rash, and sore throat, among other symptoms. Here, we report a case of a 44-year-old healthy male who developed adult-onset Still’s disease (AOSD) with atypical symptoms after both doses of ChAdOx1 nCoV-19 vaccine with 3 months of dose interval. The medical team suspected Still's disease and started prednisone 1 mg/kg (40mg). The next day the patient showed a marked improvement in articular and chest pains and had no other fever episodes. Therefore, he was discharged to continue the treatment in outpatient care. On the six-month follow-up, the patient was free of complaints, and the progressive corticoid withdrawal plan was already finished. https://www.revistas.usp.br/autopsy/article/view/204212Adenovirus VaccinesCOVID-19 VaccinesStill's DiseaseAdult-Onset |
| spellingShingle | Laíssa Fiorotti Albertino Isac Ribeiro Moulaz Tammer Ferreira Zogheib Martina Zanotti Carneiro Valentim Ketty Lysie Libardi Lira Machado Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association Autopsy and Case Reports Adenovirus Vaccines COVID-19 Vaccines Still's Disease Adult-Onset |
| title | Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association |
| title_full | Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association |
| title_fullStr | Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association |
| title_full_unstemmed | Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association |
| title_short | Adult-onset Still's disease after ChAdOx1 nCoV-19 vaccine: a possible association |
| title_sort | adult onset still s disease after chadox1 ncov 19 vaccine a possible association |
| topic | Adenovirus Vaccines COVID-19 Vaccines Still's Disease Adult-Onset |
| url | https://www.revistas.usp.br/autopsy/article/view/204212 |
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