The effects of blood pressure on post stroke cognitive impairment: BP and PSCI
Abstract Cognitive function following acute ischemic stroke (AIS) is critical to prognosis and quality of life. Hypertension is a risk factor for stroke and is associated with post stroke cognitive impairment (PSCI). However, the optimal blood pressure parameters after AIS is unknown. This is a sub‐...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14373 |
| _version_ | 1827778879415123968 |
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| author | Yue Wang Shiping Li Yuesong Pan Mengxing Wang Xiaoling Liao Jiong Shi Yongjun Wang |
| author_facet | Yue Wang Shiping Li Yuesong Pan Mengxing Wang Xiaoling Liao Jiong Shi Yongjun Wang |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Abstract Cognitive function following acute ischemic stroke (AIS) is critical to prognosis and quality of life. Hypertension is a risk factor for stroke and is associated with post stroke cognitive impairment (PSCI). However, the optimal blood pressure parameters after AIS is unknown. This is a sub‐study of the Impairment of CognitiON and Sleep after acute ischemic stroke or transient ischemic attack in Chinese patients (ICONS) study conducted between August 2015 and March 2018. Cognition was assessed at two‐week (2w), three‐month (3 m), and twelve‐month (12 m) by Montreal Cognitive Assessment (MoCA). A total of 682 participants who met the inclusion criteria were enrolled. The primary outcome was cognitive changes after 3 and 12 months post stroke. Among 682 participants, the mean age was 59.35 ± 10.40 years and 72.29% were men. PSCI patients with high systolic blood pressure (SBP ≥140 mm Hg) at 3 m not only had worse cognition as evidenced by MoCA scores at 3 m but also predicted worse scores at 12 m. When participants were stratified into cognitively stable/improved (MoCA score ≥0, 2w vs. 12 m) and cognitively impaired (MoCA score ≤‐2, 2w vs. 12 m), those with high SBP were more likely to be cognitively impaired (OR 2.17, 95%CI 1.12–4.21, p < .05) and less likely to be cognitively stable/improved (OR 0.66, 95%CI 0.44–0.99, p < .05). SBP more than 140 mm Hg is associated with worse cognitive performance after ischemic stroke. Patients with SBP lower than 140 mm Hg have better cognitive outcome at 3‐month and 1 year after stroke. |
| first_indexed | 2024-03-11T14:43:16Z |
| format | Article |
| id | doaj.art-58a1f14c46954091bf062a0bc6d2d995 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:16Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-58a1f14c46954091bf062a0bc6d2d9952023-10-30T13:26:28ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-12-0123122100210510.1111/jch.14373The effects of blood pressure on post stroke cognitive impairment: BP and PSCIYue Wang0Shiping Li1Yuesong Pan2Mengxing Wang3Xiaoling Liao4Jiong Shi5Yongjun Wang6National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaNational Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaNational Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaNational Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaNational Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaNational Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaNational Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital Capital Medical University Beijing People's Republic of ChinaAbstract Cognitive function following acute ischemic stroke (AIS) is critical to prognosis and quality of life. Hypertension is a risk factor for stroke and is associated with post stroke cognitive impairment (PSCI). However, the optimal blood pressure parameters after AIS is unknown. This is a sub‐study of the Impairment of CognitiON and Sleep after acute ischemic stroke or transient ischemic attack in Chinese patients (ICONS) study conducted between August 2015 and March 2018. Cognition was assessed at two‐week (2w), three‐month (3 m), and twelve‐month (12 m) by Montreal Cognitive Assessment (MoCA). A total of 682 participants who met the inclusion criteria were enrolled. The primary outcome was cognitive changes after 3 and 12 months post stroke. Among 682 participants, the mean age was 59.35 ± 10.40 years and 72.29% were men. PSCI patients with high systolic blood pressure (SBP ≥140 mm Hg) at 3 m not only had worse cognition as evidenced by MoCA scores at 3 m but also predicted worse scores at 12 m. When participants were stratified into cognitively stable/improved (MoCA score ≥0, 2w vs. 12 m) and cognitively impaired (MoCA score ≤‐2, 2w vs. 12 m), those with high SBP were more likely to be cognitively impaired (OR 2.17, 95%CI 1.12–4.21, p < .05) and less likely to be cognitively stable/improved (OR 0.66, 95%CI 0.44–0.99, p < .05). SBP more than 140 mm Hg is associated with worse cognitive performance after ischemic stroke. Patients with SBP lower than 140 mm Hg have better cognitive outcome at 3‐month and 1 year after stroke.https://doi.org/10.1111/jch.14373hypertensionpost stroke cognitive impairmentstroke |
| spellingShingle | Yue Wang Shiping Li Yuesong Pan Mengxing Wang Xiaoling Liao Jiong Shi Yongjun Wang The effects of blood pressure on post stroke cognitive impairment: BP and PSCI The Journal of Clinical Hypertension hypertension post stroke cognitive impairment stroke |
| title | The effects of blood pressure on post stroke cognitive impairment: BP and PSCI |
| title_full | The effects of blood pressure on post stroke cognitive impairment: BP and PSCI |
| title_fullStr | The effects of blood pressure on post stroke cognitive impairment: BP and PSCI |
| title_full_unstemmed | The effects of blood pressure on post stroke cognitive impairment: BP and PSCI |
| title_short | The effects of blood pressure on post stroke cognitive impairment: BP and PSCI |
| title_sort | effects of blood pressure on post stroke cognitive impairment bp and psci |
| topic | hypertension post stroke cognitive impairment stroke |
| url | https://doi.org/10.1111/jch.14373 |
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