Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein. In this study, we have identified protein aggre...

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Bibliographic Details
Main Authors: Katherine J. Robinson, Madelaine C. Tym, Alison Hogan, Maxinne Watchon, Kristy C. Yuan, Stuart K. Plenderleith, Emily K. Don, Angela S. Laird
Format: Article
Language:English
Published: The Company of Biologists 2021-10-01
Series:Disease Models & Mechanisms
Subjects:
spinocerebellar ataxia 3
machado–joseph disease
hereditary spinocerebellar ataxias
neurodegenerative disease
flow cytometry
proteinopathy
insoluble protein species
protein aggregates
Online Access:http://dmm.biologists.org/content/14/10/dmm049023

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