The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation
New vaccination strategies focus on achieving CD8+ T cell (CTL) immunity rather than on induction of protective antibody responses. While the requirement of CD4+ T (Th) cell help in dendritic cell (DC) activation and licensing, and in CTL memory induction has been described in several disease models...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00379/full |
| _version_ | 1817985762900049920 |
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| author | Catherine eGottschalk Elisabeth eMettke Christian eKurts |
| author_facet | Catherine eGottschalk Elisabeth eMettke Christian eKurts |
| author_sort | Catherine eGottschalk |
| collection | DOAJ |
| description | New vaccination strategies focus on achieving CD8+ T cell (CTL) immunity rather than on induction of protective antibody responses. While the requirement of CD4+ T (Th) cell help in dendritic cell (DC) activation and licensing, and in CTL memory induction has been described in several disease models, CTL responses may occur in a Th cell help independent manner. Natural Killer T cells (NKT cells) can substitute for Th cell help and license DC as well. NKT cells produce a broad spectrum of Th1 and Th2 cytokines, thereby inducing a similar set of costimulatory molecules and cytokines in DC. This form of licensing differs from Th cell help by inducing other chemokines: while Th cell licensed DC produce CCR5 ligands, NKT cell-licensed DC produce CCL17 which attracts CCR4+ CD8+ T cells for subsequent activation. It has recently been shown that iNKT cells do not only enhance immune responses against bacterial pathogens or parasites, but also play a role in viral infections. The inclusion of NKT cell ligands in Influenza virus vaccines enhanced memory CTL generation and protective immunity in a mouse model. This review will focus on the role of iNKT cells in the cross-talk with cross-priming DC and memory CD8+ T cell formation. |
| first_indexed | 2024-04-14T00:02:01Z |
| format | Article |
| id | doaj.art-58a30a6508554651ab31d04cfc53d4da |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T00:02:01Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-58a30a6508554651ab31d04cfc53d4da2022-12-22T02:23:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-07-01610.3389/fimmu.2015.00379149912The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generationCatherine eGottschalk0Elisabeth eMettke1Christian eKurts2Rheinische Friedrich Wilhelms-Universität BonnRheinische Friedrich Wilhelms-Universität BonnRheinische Friedrich Wilhelms-Universität BonnNew vaccination strategies focus on achieving CD8+ T cell (CTL) immunity rather than on induction of protective antibody responses. While the requirement of CD4+ T (Th) cell help in dendritic cell (DC) activation and licensing, and in CTL memory induction has been described in several disease models, CTL responses may occur in a Th cell help independent manner. Natural Killer T cells (NKT cells) can substitute for Th cell help and license DC as well. NKT cells produce a broad spectrum of Th1 and Th2 cytokines, thereby inducing a similar set of costimulatory molecules and cytokines in DC. This form of licensing differs from Th cell help by inducing other chemokines: while Th cell licensed DC produce CCR5 ligands, NKT cell-licensed DC produce CCL17 which attracts CCR4+ CD8+ T cells for subsequent activation. It has recently been shown that iNKT cells do not only enhance immune responses against bacterial pathogens or parasites, but also play a role in viral infections. The inclusion of NKT cell ligands in Influenza virus vaccines enhanced memory CTL generation and protective immunity in a mouse model. This review will focus on the role of iNKT cells in the cross-talk with cross-priming DC and memory CD8+ T cell formation.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00379/fullChemokinesDendritic CellsMemoryCD8 T cellscross-presentationLicensing |
| spellingShingle | Catherine eGottschalk Elisabeth eMettke Christian eKurts The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation Frontiers in Immunology Chemokines Dendritic Cells Memory CD8 T cells cross-presentation Licensing |
| title | The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation |
| title_full | The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation |
| title_fullStr | The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation |
| title_full_unstemmed | The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation |
| title_short | The role of natural killer T cells in dendritic cell licensing, cross-priming and memory CD8+ T cell generation |
| title_sort | role of natural killer t cells in dendritic cell licensing cross priming and memory cd8 t cell generation |
| topic | Chemokines Dendritic Cells Memory CD8 T cells cross-presentation Licensing |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00379/full |
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