Single-spore germination analyses reveal that calcium released during Clostridioides difficile germination functions in a feedforward loop
ABSTRACT Clostridioides difficile infections begin when its metabolically dormant spores germinate in response to sensing bile acid germinants alongside amino acid and divalent cation co-germinants in the small intestine. While bile acid germinants are essential for C. difficile spore germination, i...
Main Authors: | John W. Ribis, Luana Melo, Shailab Shrestha, David Giacalone, Enrique E. Rodriguez, Aimee Shen, Amy Rohlfing |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2023-08-01
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Series: | mSphere |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/msphere.00005-23 |
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