Single-spore germination analyses reveal that calcium released during Clostridioides difficile germination functions in a feedforward loop

Single-spore germination analyses reveal that calcium released during Clostridioides difficile germination functions in a feedforward loop

ABSTRACT Clostridioides difficile infections begin when its metabolically dormant spores germinate in response to sensing bile acid germinants alongside amino acid and divalent cation co-germinants in the small intestine. While bile acid germinants are essential for C. difficile spore germination, i...

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Bibliographic Details
Main Authors: John W. Ribis, Luana Melo, Shailab Shrestha, David Giacalone, Enrique E. Rodriguez, Aimee Shen, Amy Rohlfing
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mSphere
Subjects:
Clostridioides difficile
spore germination
time-lapse microscopy
automated image analysis
co-germinant
DPA
Online Access:https://journals.asm.org/doi/10.1128/msphere.00005-23

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