Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats
The pathogenesis of inflammatory bowel disease (IBD) is closely related to inflammatory damage and gut dysbiosis. Administering fermented milk may serve as a dietary intervention strategy of delivering bioactive substrates to consumers. This work aimed to investigate the mitigating effects of pasteu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002109 |
| _version_ | 1818552447277203456 |
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| author | Cuijiao Feng Weiqin Zhang Tao Zhang Bohai Li Qiuwen He Lai-Yu Kwok Heping Zhang |
| author_facet | Cuijiao Feng Weiqin Zhang Tao Zhang Bohai Li Qiuwen He Lai-Yu Kwok Heping Zhang |
| author_sort | Cuijiao Feng |
| collection | DOAJ |
| description | The pathogenesis of inflammatory bowel disease (IBD) is closely related to inflammatory damage and gut dysbiosis. Administering fermented milk may serve as a dietary intervention strategy of delivering bioactive substrates to consumers. This work aimed to investigate the mitigating effects of pasteurized probiotic fermented milk on dextran sulfate sodium (DSS)-induced IBD in rats. Our results showed that intragastric gavage of pasteurized probiotic fermented milk could significantly lower DAI scores, alleviate colon damage, and decrease serum tumor necrosis factor-α and interleukin-6 levels. Additionally, pasteurized probiotic fermented milk administration improved the intestinal microbial Richness index, accompanied by significant increases in beneficial bacteria and reduction in species related to host inflammation. The gut functional metagenome also shifted with pasteurized probiotic fermented milk intervention, showing significant enrichment in biosynthesis pathways of amino acids, nucleotides, and vitamins. In conclusion, ingesting pasteurized probiotic fermented milk alleviated IBD by reducing inflammatory response and restoring the gut microbiota. |
| first_indexed | 2024-12-12T09:13:19Z |
| format | Article |
| id | doaj.art-58a43949c7dc49b4b721fbc1deb3ef77 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-12T09:13:19Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-58a43949c7dc49b4b721fbc1deb3ef772022-12-22T00:29:27ZengElsevierJournal of Functional Foods1756-46462022-07-0194105140Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in ratsCuijiao Feng0Weiqin Zhang1Tao Zhang2Bohai Li3Qiuwen He4Lai-Yu Kwok5Heping Zhang6Key Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaKey Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaKey Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaKey Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaKey Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaKey Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaCorresponding author.; Key Laboratory of Dairy Biotechnology and Engineering, Key Laboratory of Dairy Products Processing, Inner Mongolia Agricultural University, Hohhot 010018, PR China; Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, PR ChinaThe pathogenesis of inflammatory bowel disease (IBD) is closely related to inflammatory damage and gut dysbiosis. Administering fermented milk may serve as a dietary intervention strategy of delivering bioactive substrates to consumers. This work aimed to investigate the mitigating effects of pasteurized probiotic fermented milk on dextran sulfate sodium (DSS)-induced IBD in rats. Our results showed that intragastric gavage of pasteurized probiotic fermented milk could significantly lower DAI scores, alleviate colon damage, and decrease serum tumor necrosis factor-α and interleukin-6 levels. Additionally, pasteurized probiotic fermented milk administration improved the intestinal microbial Richness index, accompanied by significant increases in beneficial bacteria and reduction in species related to host inflammation. The gut functional metagenome also shifted with pasteurized probiotic fermented milk intervention, showing significant enrichment in biosynthesis pathways of amino acids, nucleotides, and vitamins. In conclusion, ingesting pasteurized probiotic fermented milk alleviated IBD by reducing inflammatory response and restoring the gut microbiota.http://www.sciencedirect.com/science/article/pii/S1756464622002109Inflammatory bowel diseaseGut microbiotaPasteurized fermented milkFunctional foodProbiotics |
| spellingShingle | Cuijiao Feng Weiqin Zhang Tao Zhang Bohai Li Qiuwen He Lai-Yu Kwok Heping Zhang Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats Journal of Functional Foods Inflammatory bowel disease Gut microbiota Pasteurized fermented milk Functional food Probiotics |
| title | Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats |
| title_full | Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats |
| title_fullStr | Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats |
| title_full_unstemmed | Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats |
| title_short | Oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium-induced inflammatory bowel disease in rats |
| title_sort | oral administration of pasteurized probiotic fermented milk alleviates dextran sulfate sodium induced inflammatory bowel disease in rats |
| topic | Inflammatory bowel disease Gut microbiota Pasteurized fermented milk Functional food Probiotics |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002109 |
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