Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients
Abstract Background Since the COVID-19 outbreak, preliminary research has shown that some risk-associated conditions increase death and severe complications of the disease, hypertension being one of them. Thus, numerous meta-analyses have been conducted to explore this issue. Therefore, this umbrell...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-022-02111-2 |
| _version_ | 1811319653119557632 |
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| author | Yousof Khairy Deniz Naghibi Ahmad Moosavi Mehran Sardareh Saber Azami-Aghdash |
| author_facet | Yousof Khairy Deniz Naghibi Ahmad Moosavi Mehran Sardareh Saber Azami-Aghdash |
| author_sort | Yousof Khairy |
| collection | DOAJ |
| description | Abstract Background Since the COVID-19 outbreak, preliminary research has shown that some risk-associated conditions increase death and severe complications of the disease, hypertension being one of them. Thus, numerous meta-analyses have been conducted to explore this issue. Therefore, this umbrella review aims to perform a meta-analysis of the meta-analyses to estimate the prevalence and associated risks of hypertension in patients with COVID-19. Methods PubMed, Scopus, Web of Knowledge, Embase, and Cochrane databases were searched for the published meta-analyses up to January 1, 2022. Google Scholar, citation check, reference check, and Grey literature were also manually searched. A random-effect model approach was used for analysis. Results The overall death rate was estimated at 12%. Hypertension was present in 25% of the patients as a comorbid disease. The overall RR for death, disease severity, and the possibility of ICU admission were estimated at 1.79 [1.68–1.89 with 95% CI], 1.74 [1.66–1.83 with 95% CI], and 1.91 [1.48–2.34 with 95% CI], respectively. The meta-regression results showed that being “male” significantly increases the risk of disease severity and ICU admission. Conclusions The results indicated that hypertension is a common comorbid disease in hospitalized patients with COVID-19, which significantly increases mortality risk, the severity of the disease, and the probability of ICU admission. Systematic review registration This study has been registered in PROSPERO (CRD42021231844). |
| first_indexed | 2024-04-13T12:46:32Z |
| format | Article |
| id | doaj.art-58a52f8541b64c86974b4af454b4d7ed |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-04-13T12:46:32Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-58a52f8541b64c86974b4af454b4d7ed2022-12-22T02:46:21ZengBMCSystematic Reviews2046-40532022-11-0111111610.1186/s13643-022-02111-2Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patientsYousof Khairy0Deniz Naghibi1Ahmad Moosavi2Mehran Sardareh3Saber Azami-Aghdash4Center for the Development of Interdisciplinary Research in Islamic Sciences and Health Sciences, Tabriz University of Medical SciencesDepartment of Public Health Sciences, School of Medicine and Dentistry, University of RochesterDepartment of Health and Community Medicine, Dezful University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesTabriz Health Services Management Research Center, Tabriz University of Medical SciencesAbstract Background Since the COVID-19 outbreak, preliminary research has shown that some risk-associated conditions increase death and severe complications of the disease, hypertension being one of them. Thus, numerous meta-analyses have been conducted to explore this issue. Therefore, this umbrella review aims to perform a meta-analysis of the meta-analyses to estimate the prevalence and associated risks of hypertension in patients with COVID-19. Methods PubMed, Scopus, Web of Knowledge, Embase, and Cochrane databases were searched for the published meta-analyses up to January 1, 2022. Google Scholar, citation check, reference check, and Grey literature were also manually searched. A random-effect model approach was used for analysis. Results The overall death rate was estimated at 12%. Hypertension was present in 25% of the patients as a comorbid disease. The overall RR for death, disease severity, and the possibility of ICU admission were estimated at 1.79 [1.68–1.89 with 95% CI], 1.74 [1.66–1.83 with 95% CI], and 1.91 [1.48–2.34 with 95% CI], respectively. The meta-regression results showed that being “male” significantly increases the risk of disease severity and ICU admission. Conclusions The results indicated that hypertension is a common comorbid disease in hospitalized patients with COVID-19, which significantly increases mortality risk, the severity of the disease, and the probability of ICU admission. Systematic review registration This study has been registered in PROSPERO (CRD42021231844).https://doi.org/10.1186/s13643-022-02111-2Comorbid diseaseCOVID-19HypertensionMeta-analysisRisk factor |
| spellingShingle | Yousof Khairy Deniz Naghibi Ahmad Moosavi Mehran Sardareh Saber Azami-Aghdash Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients Systematic Reviews Comorbid disease COVID-19 Hypertension Meta-analysis Risk factor |
| title | Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients |
| title_full | Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients |
| title_fullStr | Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients |
| title_full_unstemmed | Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients |
| title_short | Prevalence of hypertension and associated risks in hospitalized patients with COVID-19: a meta-analysis of meta-analyses with 1468 studies and 1,281,510 patients |
| title_sort | prevalence of hypertension and associated risks in hospitalized patients with covid 19 a meta analysis of meta analyses with 1468 studies and 1 281 510 patients |
| topic | Comorbid disease COVID-19 Hypertension Meta-analysis Risk factor |
| url | https://doi.org/10.1186/s13643-022-02111-2 |
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