Microbiota-Dependent Upregulation of Bitter Taste Receptor Subtypes in the Mouse Large Intestine in High-Fat Diet-Induced Obesity

Microbiota-Dependent Upregulation of Bitter Taste Receptor Subtypes in the Mouse Large Intestine in High-Fat Diet-Induced Obesity

Bitter taste receptors (Tas2rs in mice) detect bitterness, a warning signal for toxins and poisons, and are expressed in enteroendocrine cells. We tested the hypothesis that Tas2r138 and Tas2r116 mRNAs are modulated by microbiota alterations induced by a long-term high-fat diet (HFD) and antibiotics...

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Bibliographic Details
Main Authors: Filippo Caremoli, Jennifer Huynh, Venu Lagishetty, Daniela Markovic, Jonathan Braun, Tien S. Dong, Jonathan P. Jacobs, Catia Sternini
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Nutrients
Subjects:
antibiotics
dysbiosis
gut
microbiome
enteroendocrine cells
peptides
Online Access:https://www.mdpi.com/2072-6643/15/19/4145

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