Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation

Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation

Epileptogenesis is a common consequence of brain insults, however, the prevention or delay of the epileptogenic process remains an important unmet medical challenge. Overexpression of glycine transporter 1 (GlyT1) is proposed as a pathological hallmark in the hippocampus of patients with temporal lo...

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Bibliographic Details
Main Authors: Hai-Ying Shen, Landen Weltha, John M. Cook, Raey Gesese, Wakaba Omi, Sadie B. Baer, Rizelle Mae Rose, Jesica Reemmer, Detlev Boison
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
epileptogenesis
sarcosine
DNA methylation
dentate gyrus
GlyT1 inhibition
TET1
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00097/full

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