Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression
Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2024;volume=15;issue=2;spage=252;epage=254;aulast=Kamboj |
| _version_ | 1827309536048840704 |
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| author | Parul Kamboj Geeti Khullar Sanjeev Handa Arnab Pal Uma Nahar Saikia Dipankar De |
| author_facet | Parul Kamboj Geeti Khullar Sanjeev Handa Arnab Pal Uma Nahar Saikia Dipankar De |
| author_sort | Parul Kamboj |
| collection | DOAJ |
| description | Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating this pathway. Aim: To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of FoxO1, peroxisome proliferator-activated receptor (PPARγ), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients. Results: The gene expression of FoxO1 was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in FoxO1 expression in acne patients at mRNA (P = 0.05) level was observed. There was a significant decrease in grade 3 positivity of FoxO1 at protein level (P = 0.0009). A decrease in androgen receptor positivity (P = 0.055) at protein level was also observed. Conclusion: Reduction in FoxO1 expression appears to be an important mechanism of action of isotretinoin in acne. |
| first_indexed | 2024-04-24T19:42:58Z |
| format | Article |
| id | doaj.art-58a8dfb8314344bda418f7d4a36e87b3 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-04-24T19:42:58Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-58a8dfb8314344bda418f7d4a36e87b32024-03-25T10:27:44ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782024-01-0115225225410.4103/idoj.idoj_455_23Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expressionParul KambojGeeti KhullarSanjeev HandaArnab PalUma Nahar SaikiaDipankar DeBackground: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating this pathway. Aim: To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of FoxO1, peroxisome proliferator-activated receptor (PPARγ), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients. Results: The gene expression of FoxO1 was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in FoxO1 expression in acne patients at mRNA (P = 0.05) level was observed. There was a significant decrease in grade 3 positivity of FoxO1 at protein level (P = 0.0009). A decrease in androgen receptor positivity (P = 0.055) at protein level was also observed. Conclusion: Reduction in FoxO1 expression appears to be an important mechanism of action of isotretinoin in acne.http://www.idoj.in/article.asp?issn=2229-5178;year=2024;volume=15;issue=2;spage=252;epage=254;aulast=Kambojacneandrogen receptorfoxo1isotretinoinperoxisome proliferator-activated receptor |
| spellingShingle | Parul Kamboj Geeti Khullar Sanjeev Handa Arnab Pal Uma Nahar Saikia Dipankar De Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression Indian Dermatology Online Journal acne androgen receptor foxo1 isotretinoin peroxisome proliferator-activated receptor |
| title | Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression |
| title_full | Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression |
| title_fullStr | Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression |
| title_full_unstemmed | Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression |
| title_short | Role of FoxO1 in acne and effect of isotretinoin on FoxO1 expression |
| title_sort | role of foxo1 in acne and effect of isotretinoin on foxo1 expression |
| topic | acne androgen receptor foxo1 isotretinoin peroxisome proliferator-activated receptor |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2024;volume=15;issue=2;spage=252;epage=254;aulast=Kamboj |
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