De novo design of a pH-triggered self-assembled β-hairpin nanopeptide with the dual biological functions for antibacterial and entrapment

De novo design of a pH-triggered self-assembled β-hairpin nanopeptide with the dual biological functions for antibacterial and entrapment

Abstract Background Acid-tolerant enteric pathogens can evade small intestinal acid barriers, colonize and infect the intestinal tract. However, broad-spectrum antibiotics are not the best therapeutic strategy because of the disruption of intestinal flora caused by its indiscriminate antimicrobial a...

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Bibliographic Details
Main Authors: Qiuke Li, Jinze Li, Weikang Yu, Zhihua Wang, Jiawei Li, Xingjun Feng, Jiajun Wang, Anshan Shan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Nanobiotechnology
Subjects:
Histidine functioned
pH-triggered self-assembled peptide
Antimicrobial activity
Entrapment property
β-hairpin structure
Online Access:https://doi.org/10.1186/s12951-021-00927-z

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