Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model
Background/Aims: Endoscopic band ligation (EBL) is an accepted method in the management of variceal bleeding; however, there is little evidence on the safety and feasibility of EBL for the closure of bowel perforation. In this study, we aimed to evaluate the technical feasibility and efficacy of EBL...
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2015-11-01
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| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-48-6-534.pdf |
| _version_ | 1797668567436492800 |
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| author | Joung-Ho Han Myounghwan Kim Tae Hoon Lee Hyun Kim Yunho Jung Seon Mee Park Heebok Chae Seijin Youn Ji Yun Shin In-Kwang Lee Tae Soo Lee Seok Hwa Choi |
| author_facet | Joung-Ho Han Myounghwan Kim Tae Hoon Lee Hyun Kim Yunho Jung Seon Mee Park Heebok Chae Seijin Youn Ji Yun Shin In-Kwang Lee Tae Soo Lee Seok Hwa Choi |
| author_sort | Joung-Ho Han |
| collection | DOAJ |
| description | Background/Aims: Endoscopic band ligation (EBL) is an accepted method in the management of variceal bleeding; however, there is little evidence on the safety and feasibility of EBL for the closure of bowel perforation. In this study, we aimed to evaluate the technical feasibility and efficacy of EBL in iatrogenic colon perforation by using a canine model. Methods: We established an iatrogenic colon perforation model by using seven beagle dogs. Longitudinal 1.5- to 1.7-cm colon perforations were created with a needle knife and an insulated-tip knife, and the perforation was subsequently closed with EBL. During a 2-week follow-up period, the animals were carefully monitored and then euthanized for pathologic examination. Results: The EBL of iatrogenic colon perforations was successful in all dogs. The mean procedure time for EBL closure with one to three bands was 191.7 seconds, and there were no immediate complications. One animal was euthanized after 3 days because of peritonitis. There were no clinical and laboratory features of sepsis or peritonitis in the remaining six animals. On necropsy, we did not find any fecal peritonitis, pericolonic abscess formation, or transmural dehiscence at the perforation site. Histopathology demonstrated inflamed granulation tissue and scar lesions replaced by fibrosis. Conclusions: EBL might be a feasible and safe method for the management of iatrogenic colon perforations in an in vivo model. |
| first_indexed | 2024-03-11T20:31:14Z |
| format | Article |
| id | doaj.art-58a969ea78564995ae0daa9823991520 |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-11T20:31:14Z |
| publishDate | 2015-11-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-58a969ea78564995ae0daa98239915202023-10-02T08:51:34ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432015-11-0148653454110.5946/ce.2015.48.6.5346798Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine ModelJoung-Ho Han0Myounghwan Kim1Tae Hoon Lee2Hyun Kim3Yunho Jung4Seon Mee Park5Heebok Chae6Seijin Youn7Ji Yun Shin8In-Kwang Lee9Tae Soo Lee10Seok Hwa Choi11 Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea Department of Veterinary Surgery, Chungbuk National University College of Veterinary Medicine, Cheongju, Korea Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea Department of Biomedical Engineering, Chungbuk National University College of Medicine, Cheongju, Korea Department of Biomedical Engineering, Chungbuk National University College of Medicine, Cheongju, Korea Department of Biomedical Engineering, Chungbuk National University College of Medicine, Cheongju, Korea Department of Veterinary Surgery, Chungbuk National University College of Veterinary Medicine, Cheongju, KoreaBackground/Aims: Endoscopic band ligation (EBL) is an accepted method in the management of variceal bleeding; however, there is little evidence on the safety and feasibility of EBL for the closure of bowel perforation. In this study, we aimed to evaluate the technical feasibility and efficacy of EBL in iatrogenic colon perforation by using a canine model. Methods: We established an iatrogenic colon perforation model by using seven beagle dogs. Longitudinal 1.5- to 1.7-cm colon perforations were created with a needle knife and an insulated-tip knife, and the perforation was subsequently closed with EBL. During a 2-week follow-up period, the animals were carefully monitored and then euthanized for pathologic examination. Results: The EBL of iatrogenic colon perforations was successful in all dogs. The mean procedure time for EBL closure with one to three bands was 191.7 seconds, and there were no immediate complications. One animal was euthanized after 3 days because of peritonitis. There were no clinical and laboratory features of sepsis or peritonitis in the remaining six animals. On necropsy, we did not find any fecal peritonitis, pericolonic abscess formation, or transmural dehiscence at the perforation site. Histopathology demonstrated inflamed granulation tissue and scar lesions replaced by fibrosis. Conclusions: EBL might be a feasible and safe method for the management of iatrogenic colon perforations in an in vivo model.http://www.e-ce.org/upload/pdf/ce-48-6-534.pdfColon perforationEndoscopic band ligationComplication |
| spellingShingle | Joung-Ho Han Myounghwan Kim Tae Hoon Lee Hyun Kim Yunho Jung Seon Mee Park Heebok Chae Seijin Youn Ji Yun Shin In-Kwang Lee Tae Soo Lee Seok Hwa Choi Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model Clinical Endoscopy Colon perforation Endoscopic band ligation Complication |
| title | Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model |
| title_full | Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model |
| title_fullStr | Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model |
| title_full_unstemmed | Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model |
| title_short | Endoluminal Closure of Colon Perforation with Endoscopic Band Ligation: Technical Feasibility and Safety in an Canine Model |
| title_sort | endoluminal closure of colon perforation with endoscopic band ligation technical feasibility and safety in an canine model |
| topic | Colon perforation Endoscopic band ligation Complication |
| url | http://www.e-ce.org/upload/pdf/ce-48-6-534.pdf |
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