Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2
Abstract Proton magnetic resonance (MR) imaging to quantify regional ventilation–perfusion ( V˙A/Q˙) ratios combines specific ventilation imaging (SVI) and separate proton density and perfusion measures into a composite map. Specific ventilation imaging exploits the paramagnetic properties of O2, wh...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-07-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.14488 |
| _version_ | 1819226668987842560 |
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| author | Ann R. Elliott Abhilash S. Kizhakke Puliyakote Vincent Tedjasaputra Beni Pazár Harrieth Wagner Rui C. Sá Jeremy E. Orr G. Kim Prisk Peter D. Wagner Susan R. Hopkins |
| author_facet | Ann R. Elliott Abhilash S. Kizhakke Puliyakote Vincent Tedjasaputra Beni Pazár Harrieth Wagner Rui C. Sá Jeremy E. Orr G. Kim Prisk Peter D. Wagner Susan R. Hopkins |
| author_sort | Ann R. Elliott |
| collection | DOAJ |
| description | Abstract Proton magnetic resonance (MR) imaging to quantify regional ventilation–perfusion ( V˙A/Q˙) ratios combines specific ventilation imaging (SVI) and separate proton density and perfusion measures into a composite map. Specific ventilation imaging exploits the paramagnetic properties of O2, which alters the local MR signal intensity, in an FIO2‐dependent manner. Specific ventilation imaging data are acquired during five wash‐in/wash‐out cycles of breathing 21% O2 alternating with 100% O2 over ~20 min. This technique assumes that alternating FIO2 does not affect V˙A/Q˙ heterogeneity, but this is unproven. We tested the hypothesis that alternating FIO2 exposure increases V˙A/Q˙ mismatch in nine patients with abnormal pulmonary gas exchange and increased V˙A/Q˙ mismatch using the multiple inert gas elimination technique (MIGET).The following data were acquired (a) breathing air (baseline), (b) breathing alternating air/100% O2 during an emulated‐SVI protocol (eSVI), and (c) 20 min after ambient air breathing (recovery). MIGET heterogeneity indices of shunt, deadspace, ventilation versus V˙A/Q˙ ratio, LogSD V˙, and perfusion versus V˙A/Q˙ ratio, LogSD Q˙ were calculated. LogSD V˙ was not different between eSVI and baseline (1.04 ± 0.39 baseline, 1.05 ± 0.38 eSVI, p = .84); but was reduced compared to baseline during recovery (0.97 ± 0.39, p = .04). There was no significant difference in LogSD Q˙ across conditions (0.81 ± 0.30 baseline, 0.79 ± 0.15 eSVI, 0.79 ± 0.20 recovery; p = .54); Deadspace was not significantly different (p = .54) but shunt showed a borderline increase during eSVI (1.0% ± 1.0 baseline, 2.6% ± 2.9 eSVI; p = .052) likely from altered hypoxic pulmonary vasoconstriction and/or absorption atelectasis. Intermittent breathing of 100% O2 does not substantially alter V˙A/Q˙ matching and if SVI measurements are made after perfusion measurements, any potential effects will be minimized. |
| first_indexed | 2024-12-23T10:29:09Z |
| format | Article |
| id | doaj.art-58a9fee3a67c46ffb8a8d293e1b0d1bc |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-23T10:29:09Z |
| publishDate | 2020-07-01 |
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| spelling | doaj.art-58a9fee3a67c46ffb8a8d293e1b0d1bc2022-12-21T17:50:29ZengWileyPhysiological Reports2051-817X2020-07-01813n/an/a10.14814/phy2.14488Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2Ann R. Elliott0Abhilash S. Kizhakke Puliyakote1Vincent Tedjasaputra2Beni Pazár3Harrieth Wagner4Rui C. Sá5Jeremy E. Orr6G. Kim Prisk7Peter D. Wagner8Susan R. Hopkins9Department of Medicine University of California San Diego La Jolla CA USAThe Pulmonary Imaging Laboratory University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USAThe Pulmonary Imaging Laboratory University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USADepartment of Medicine University of California San Diego La Jolla CA USAAbstract Proton magnetic resonance (MR) imaging to quantify regional ventilation–perfusion ( V˙A/Q˙) ratios combines specific ventilation imaging (SVI) and separate proton density and perfusion measures into a composite map. Specific ventilation imaging exploits the paramagnetic properties of O2, which alters the local MR signal intensity, in an FIO2‐dependent manner. Specific ventilation imaging data are acquired during five wash‐in/wash‐out cycles of breathing 21% O2 alternating with 100% O2 over ~20 min. This technique assumes that alternating FIO2 does not affect V˙A/Q˙ heterogeneity, but this is unproven. We tested the hypothesis that alternating FIO2 exposure increases V˙A/Q˙ mismatch in nine patients with abnormal pulmonary gas exchange and increased V˙A/Q˙ mismatch using the multiple inert gas elimination technique (MIGET).The following data were acquired (a) breathing air (baseline), (b) breathing alternating air/100% O2 during an emulated‐SVI protocol (eSVI), and (c) 20 min after ambient air breathing (recovery). MIGET heterogeneity indices of shunt, deadspace, ventilation versus V˙A/Q˙ ratio, LogSD V˙, and perfusion versus V˙A/Q˙ ratio, LogSD Q˙ were calculated. LogSD V˙ was not different between eSVI and baseline (1.04 ± 0.39 baseline, 1.05 ± 0.38 eSVI, p = .84); but was reduced compared to baseline during recovery (0.97 ± 0.39, p = .04). There was no significant difference in LogSD Q˙ across conditions (0.81 ± 0.30 baseline, 0.79 ± 0.15 eSVI, 0.79 ± 0.20 recovery; p = .54); Deadspace was not significantly different (p = .54) but shunt showed a borderline increase during eSVI (1.0% ± 1.0 baseline, 2.6% ± 2.9 eSVI; p = .052) likely from altered hypoxic pulmonary vasoconstriction and/or absorption atelectasis. Intermittent breathing of 100% O2 does not substantially alter V˙A/Q˙ matching and if SVI measurements are made after perfusion measurements, any potential effects will be minimized.https://doi.org/10.14814/phy2.14488hyperoxiamagnetic resonance imagingpulmonary perfusion distributionpulmonary ventilation distributionspecific ventilation imagingventilation‐perfusion ratio |
| spellingShingle | Ann R. Elliott Abhilash S. Kizhakke Puliyakote Vincent Tedjasaputra Beni Pazár Harrieth Wagner Rui C. Sá Jeremy E. Orr G. Kim Prisk Peter D. Wagner Susan R. Hopkins Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2 Physiological Reports hyperoxia magnetic resonance imaging pulmonary perfusion distribution pulmonary ventilation distribution specific ventilation imaging ventilation‐perfusion ratio |
| title | Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2 |
| title_full | Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2 |
| title_fullStr | Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2 |
| title_full_unstemmed | Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2 |
| title_short | Ventilation–perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2 |
| title_sort | ventilation perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100 o2 |
| topic | hyperoxia magnetic resonance imaging pulmonary perfusion distribution pulmonary ventilation distribution specific ventilation imaging ventilation‐perfusion ratio |
| url | https://doi.org/10.14814/phy2.14488 |
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