Macroautophagy in T lymphocyte development and function
Macroautophagy (referred to as autophagy) is a fundamental intracellular process characterized by the sequestration of cytoplasmic compartments through double-membrane vesicles, termed autophagosomes. Recent studies have established important roles of autophagy in regulating T lymphocyte development...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00022/full |
| _version_ | 1818229260932874240 |
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| author | You-Wen eHe Ming-Xiao eHe Ian eMcleod Wei eJia |
| author_facet | You-Wen eHe Ming-Xiao eHe Ian eMcleod Wei eJia |
| author_sort | You-Wen eHe |
| collection | DOAJ |
| description | Macroautophagy (referred to as autophagy) is a fundamental intracellular process characterized by the sequestration of cytoplasmic compartments through double-membrane vesicles, termed autophagosomes. Recent studies have established important roles of autophagy in regulating T lymphocyte development and function. Resting T lymphocytes have basal levels of autophagy that is upregulated by TCR stimulation. Several specific knockout or transgenic models have been developed during the past few years, and it has been revealed that autophagy plays an essential role in regulating thymocyte selection, peripheral T cell survival and proliferation. The regulation of T cell development and function by autophagy is mediated through its role in regulating self-antigen presentation, intracellular organelle homeostasis and energy production. Here we will review the current findings concerning how autophagy regulates T cell function, as well as compare different models in studying autophagy in T lymphocytes. |
| first_indexed | 2024-12-12T10:15:47Z |
| format | Article |
| id | doaj.art-58ac7ca68baf409f88df6d686c984e2c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T10:15:47Z |
| publishDate | 2012-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-58ac7ca68baf409f88df6d686c984e2c2022-12-22T00:27:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-02-01310.3389/fimmu.2012.0002220283Macroautophagy in T lymphocyte development and functionYou-Wen eHe0Ming-Xiao eHe1Ian eMcleod2Wei eJia3Duke University Medical CenterDuke University Medical CenterDuke University Medical CenterDuke University Medical CenterMacroautophagy (referred to as autophagy) is a fundamental intracellular process characterized by the sequestration of cytoplasmic compartments through double-membrane vesicles, termed autophagosomes. Recent studies have established important roles of autophagy in regulating T lymphocyte development and function. Resting T lymphocytes have basal levels of autophagy that is upregulated by TCR stimulation. Several specific knockout or transgenic models have been developed during the past few years, and it has been revealed that autophagy plays an essential role in regulating thymocyte selection, peripheral T cell survival and proliferation. The regulation of T cell development and function by autophagy is mediated through its role in regulating self-antigen presentation, intracellular organelle homeostasis and energy production. Here we will review the current findings concerning how autophagy regulates T cell function, as well as compare different models in studying autophagy in T lymphocytes.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00022/fullApoptosisAutophagyT lymphocyteorganelle homeostasisThymocyte selection |
| spellingShingle | You-Wen eHe Ming-Xiao eHe Ian eMcleod Wei eJia Macroautophagy in T lymphocyte development and function Frontiers in Immunology Apoptosis Autophagy T lymphocyte organelle homeostasis Thymocyte selection |
| title | Macroautophagy in T lymphocyte development and function |
| title_full | Macroautophagy in T lymphocyte development and function |
| title_fullStr | Macroautophagy in T lymphocyte development and function |
| title_full_unstemmed | Macroautophagy in T lymphocyte development and function |
| title_short | Macroautophagy in T lymphocyte development and function |
| title_sort | macroautophagy in t lymphocyte development and function |
| topic | Apoptosis Autophagy T lymphocyte organelle homeostasis Thymocyte selection |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00022/full |
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