Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles
Objective This prospective study aimed to assess the effect of short-acting gonadotropin-releasing hormone agonist (GnRHa) administration on pregnancy outcomes in frozen–thawed embryo transfer (FET) cycles. Methods Patients who planned to have FET in Peking Union Medical College Hospital (China) wer...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605211012247 |
| _version_ | 1828956437008613376 |
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| author | Hanbi Wang Xian Tang Orhan Bukulmez Chengyan Deng Qi Yu Yuanzheng Zhou Zhengyi Sun Jingran Zhen Xue Wang Meizhi Liu |
| author_facet | Hanbi Wang Xian Tang Orhan Bukulmez Chengyan Deng Qi Yu Yuanzheng Zhou Zhengyi Sun Jingran Zhen Xue Wang Meizhi Liu |
| author_sort | Hanbi Wang |
| collection | DOAJ |
| description | Objective This prospective study aimed to assess the effect of short-acting gonadotropin-releasing hormone agonist (GnRHa) administration on pregnancy outcomes in frozen–thawed embryo transfer (FET) cycles. Methods Patients who planned to have FET in Peking Union Medical College Hospital (China) were recruited for this study and randomly assigned into two groups. Patients in the experimental group (n = 460) received triptorelin acetate on the day of embryo transfer along with routine luteal support. Patients in the control group (n = 433) only received luteal support. One dose (0.1 mg) of a short-acting GnRHa was administered on the day of blastocyte transfer. The rates for clinical pregnancy, biochemical pregnancy, implantation, miscarriage, and ectopic pregnancy were compared between the groups. Results There were no significant differences in the number and quality of blastocytes transferred between the two groups. In the experimental and control groups, the clinical pregnancy rate was 56.3% and 50.58%, the biochemical pregnancy rate was 15.78% and 18.94%, and the median implantation rate was 39.98% and 38.01%, respectively, with no significant difference between the groups. Biochemical pregnancy and abortion and the ectopic pregnancy rate were not significantly different between the two groups. Conclusion In FET cycles, a GnRHa does not affect the pregnancy outcome. |
| first_indexed | 2024-12-14T08:10:45Z |
| format | Article |
| id | doaj.art-58ad4d0cc58547349e21bb04593973d2 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-14T08:10:45Z |
| publishDate | 2021-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-58ad4d0cc58547349e21bb04593973d22022-12-21T23:10:04ZengSAGE PublishingJournal of International Medical Research1473-23002021-05-014910.1177/03000605211012247Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cyclesHanbi WangXian TangOrhan BukulmezChengyan DengQi YuYuanzheng ZhouZhengyi SunJingran ZhenXue WangMeizhi LiuObjective This prospective study aimed to assess the effect of short-acting gonadotropin-releasing hormone agonist (GnRHa) administration on pregnancy outcomes in frozen–thawed embryo transfer (FET) cycles. Methods Patients who planned to have FET in Peking Union Medical College Hospital (China) were recruited for this study and randomly assigned into two groups. Patients in the experimental group (n = 460) received triptorelin acetate on the day of embryo transfer along with routine luteal support. Patients in the control group (n = 433) only received luteal support. One dose (0.1 mg) of a short-acting GnRHa was administered on the day of blastocyte transfer. The rates for clinical pregnancy, biochemical pregnancy, implantation, miscarriage, and ectopic pregnancy were compared between the groups. Results There were no significant differences in the number and quality of blastocytes transferred between the two groups. In the experimental and control groups, the clinical pregnancy rate was 56.3% and 50.58%, the biochemical pregnancy rate was 15.78% and 18.94%, and the median implantation rate was 39.98% and 38.01%, respectively, with no significant difference between the groups. Biochemical pregnancy and abortion and the ectopic pregnancy rate were not significantly different between the two groups. Conclusion In FET cycles, a GnRHa does not affect the pregnancy outcome.https://doi.org/10.1177/03000605211012247 |
| spellingShingle | Hanbi Wang Xian Tang Orhan Bukulmez Chengyan Deng Qi Yu Yuanzheng Zhou Zhengyi Sun Jingran Zhen Xue Wang Meizhi Liu Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles Journal of International Medical Research |
| title | Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles |
| title_full | Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles |
| title_fullStr | Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles |
| title_full_unstemmed | Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles |
| title_short | Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles |
| title_sort | single dose administration of a short acting gonadotropin releasing hormone agonist does not affect cycle outcome in frozen thawed embryo transfer cycles |
| url | https://doi.org/10.1177/03000605211012247 |
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