Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments

This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering...

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Main Author: Jeffrey eAtkinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-04-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00022/full
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author Jeffrey eAtkinson
author_facet Jeffrey eAtkinson
author_sort Jeffrey eAtkinson
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description This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between Inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.
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spelling doaj.art-58ada421acb14a2298eaa3d746e430fe2022-12-21T20:05:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122011-04-01210.3389/fphar.2011.0002210573Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developmentsJeffrey eAtkinson0Nancy UniversityThis review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between Inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00022/fullBlood PressureStrokeangiotensincerebral circulationrat modelangiotensin AT1 receptor blockers
spellingShingle Jeffrey eAtkinson
Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments
Frontiers in Pharmacology
Blood Pressure
Stroke
angiotensin
cerebral circulation
rat model
angiotensin AT1 receptor blockers
title Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments
title_full Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments
title_fullStr Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments
title_full_unstemmed Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments
title_short Stroke, high blood pressure and the renin-angiotensin-aldosterone system – new developments
title_sort stroke high blood pressure and the renin angiotensin aldosterone system new developments
topic Blood Pressure
Stroke
angiotensin
cerebral circulation
rat model
angiotensin AT1 receptor blockers
url http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00022/full
work_keys_str_mv AT jeffreyeatkinson strokehighbloodpressureandthereninangiotensinaldosteronesystemnewdevelopments