Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A.

Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A.

<h4>Objectives</h4>Inhibition of pregnancy-associated plasma protein-A (PAPP-A), an upstream activator of the insulin-like growth factor (IGF) pathway, is known to augment sensitivity to platinum-based chemotherapy. This study further tests the efficacy of PAPP-A inhibition with a monocl...

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Bibliographic Details
Main Authors: Diogo Torres, Xiaonan Hou, Laurie Bale, Ethan P Heinzen, Matthew J Maurer, Valentina Zanfagnin, Ann L Oberg, Cheryl Conover, S John Weroha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0224564

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