Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

Identification of galectin-1 and other cellular targets of alpha,beta-unsaturated carbonyl compounds, including dimethylfumarate, by use of click-chemistry probes

α,β-Unsaturated carbonyls are a common motif in environmental toxins (e.g. acrolein) as well as therapeutic drugs, including dimethylfumarate (DMFU) and monomethylfumarate (MMFU), which are used to treat multiple sclerosis and psoriasis. These compounds form adducts with protein Cys residues as well...

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Bibliographic Details
Main Authors: Max B. Sauerland, Christina Helm, Lasse G. Lorentzen, Asmita Manandhar, Trond Ulven, Luke F. Gamon, Michael J. Davies
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
Dimethylfumarate
Unsaturated carbonyls
Michael adduct
Click chemistry
Galectin
Electrophile
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003329

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