Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc

Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc

Abstract Copy number alterations (CNAs) are among the most important genetic events in cancer, but their detection from sequencing data is challenging because of unknown sample purity, tumor ploidy, and general intra-tumor heterogeneity. Here, we present CNAqc, an evolution-inspired method to perfor...

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Bibliographic Details
Main Authors: Alice Antonello, Riccardo Bergamin, Nicola Calonaci, Jacob Househam, Salvatore Milite, Marc J. Williams, Fabio Anselmi, Alberto d’Onofrio, Vasavi Sundaram, Alona Sosinsky, William C. H. Cross, Giulio Caravagna
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-024-03170-5

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