Migraine and peripheral inflammation
Aim: Migraine is a common headache disorder that may be associated with inflammation and vascular diseases. We evaluated C-reactive protein and the number of immune cells in the peripheral blood of young adult patients with migraine.Patients and Methods: This case–control study included 520 subjects...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Alanya Alaaddin Keykubat University
2017-12-01
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| Series: | Acta Medica Alanya |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/pub/medalanya/issue/32958/336902?publisher=alku |
| _version_ | 1797906158295449600 |
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| author | Aynur Yılmaz Avcı Oktay Akali̇n |
| author_facet | Aynur Yılmaz Avcı Oktay Akali̇n |
| author_sort | Aynur Yılmaz Avcı |
| collection | DOAJ |
| description | Aim: Migraine is a common
headache disorder that may be associated with inflammation and vascular
diseases. We evaluated C-reactive protein and the number of immune cells in the
peripheral blood of young adult patients with migraine.Patients and
Methods:
This case–control study included 520 subjects: 260 patients with migraine
(without aura, 169 patients; with aura, 91 patients) and 260 healthy control
subjects (age range, 18–50 years). Participants had no known anemia, vascular
risk factors, or inflammatory diseases. We evaluated serum C-reactive protein
and complete blood count parameters in patients with migraine and control
subjects.Results: C-reactive protein level,
leukocyte, neutrophillymphocyte, platelet counts and mean platelet volume
significantly differed in patients with migraine compared to controls
(P<0.001). However, with the exception of C-reactive protein, these
parameters were similar in migraine with and without aura. Logistic regression
analysis showed that migraine was significantly associated with C-reactive
protein level (odds ratio [OR], 2.36; 95% confidence interval [CI],
1.73–3.23; P<0.001), MPV (OR, 2.32; 95% CI, 1.78–3.0;
P<0.001), and leukocyte count (OR, 1.61; 95% CI,
1.32–1.94;).
Conclusion: Increased levels of
peripheral inflammation may occur in patients with migraine and may be involved
in the pathogenesis of migraine. |
| first_indexed | 2024-04-10T10:16:37Z |
| format | Article |
| id | doaj.art-58afe05569564b659327c7782f3c9459 |
| institution | Directory Open Access Journal |
| issn | 2587-0319 |
| language | English |
| last_indexed | 2024-04-10T10:16:37Z |
| publishDate | 2017-12-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj.art-58afe05569564b659327c7782f3c94592023-02-15T16:21:49ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192017-12-011312713410.30565/medalanya.336902727Migraine and peripheral inflammationAynur Yılmaz Avcı0Oktay Akali̇n1Başkent Üniversitesi HastanesiBaşkent Üniversitesi HastanesiAim: Migraine is a common headache disorder that may be associated with inflammation and vascular diseases. We evaluated C-reactive protein and the number of immune cells in the peripheral blood of young adult patients with migraine.Patients and Methods: This case–control study included 520 subjects: 260 patients with migraine (without aura, 169 patients; with aura, 91 patients) and 260 healthy control subjects (age range, 18–50 years). Participants had no known anemia, vascular risk factors, or inflammatory diseases. We evaluated serum C-reactive protein and complete blood count parameters in patients with migraine and control subjects.Results: C-reactive protein level, leukocyte, neutrophillymphocyte, platelet counts and mean platelet volume significantly differed in patients with migraine compared to controls (P<0.001). However, with the exception of C-reactive protein, these parameters were similar in migraine with and without aura. Logistic regression analysis showed that migraine was significantly associated with C-reactive protein level (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.73–3.23; P<0.001), MPV (OR, 2.32; 95% CI, 1.78–3.0; P<0.001), and leukocyte count (OR, 1.61; 95% CI, 1.32–1.94;). Conclusion: Increased levels of peripheral inflammation may occur in patients with migraine and may be involved in the pathogenesis of migraine.https://dergipark.org.tr/en/pub/medalanya/issue/32958/336902?publisher=alkucomplete blood countc-reactive proteinheadacheleukocytelymphocyteplatelettam kan sayımıc-reaktif proteinbaşağrısılökositlenfosittrombosit |
| spellingShingle | Aynur Yılmaz Avcı Oktay Akali̇n Migraine and peripheral inflammation Acta Medica Alanya complete blood count c-reactive protein headache leukocyte lymphocyte platelet tam kan sayımı c-reaktif protein başağrısı lökosit lenfosit trombosit |
| title | Migraine and peripheral inflammation |
| title_full | Migraine and peripheral inflammation |
| title_fullStr | Migraine and peripheral inflammation |
| title_full_unstemmed | Migraine and peripheral inflammation |
| title_short | Migraine and peripheral inflammation |
| title_sort | migraine and peripheral inflammation |
| topic | complete blood count c-reactive protein headache leukocyte lymphocyte platelet tam kan sayımı c-reaktif protein başağrısı lökosit lenfosit trombosit |
| url | https://dergipark.org.tr/en/pub/medalanya/issue/32958/336902?publisher=alku |
| work_keys_str_mv | AT aynuryılmazavcı migraineandperipheralinflammation AT oktayakalin migraineandperipheralinflammation |