Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats
Muscle atrophy is a reduction of muscle mass and size that occurs after the age of 30. The effects of the solid dispersions of curcumin (CURSD) and gamma-oryzanol (GOSD) were investigated on skeletal muscle of middle-aged Sprague-Dawley rats (12 months old) and compared to young rats (4 months old)....
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003887 |
| _version_ | 1811300248631377920 |
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| author | Pattarawadee Taengthong Ittipon Phoungpetchara Onrawee Khongsombat Sakara Tunsophon |
| author_facet | Pattarawadee Taengthong Ittipon Phoungpetchara Onrawee Khongsombat Sakara Tunsophon |
| author_sort | Pattarawadee Taengthong |
| collection | DOAJ |
| description | Muscle atrophy is a reduction of muscle mass and size that occurs after the age of 30. The effects of the solid dispersions of curcumin (CURSD) and gamma-oryzanol (GOSD) were investigated on skeletal muscle of middle-aged Sprague-Dawley rats (12 months old) and compared to young rats (4 months old). A mixture of CURSD and GOSD supplements (GO-CURSD) increased antioxidant enzymes through the Nrf2 pathway which caused a reduction in lipid peroxidation and pro-inflammations, resulting in less muscle damage. The GO-CURSD increased IRS1-AKT-mTOR activity and suppressed Atrogin-1 and MuRF-1 genes, resulting in increased muscle mass and cross-sectional area. In addition, the GO-CURSD increased muscular glucose uptake and glycogen via IRS1-Akt up-regulated GLUT4 expression. These results suggest that the synergistic effect of CURSD and GOSD against age-related muscle atrophy regulated by increasing the antioxidant and anti-inflammatory activities, as well as improving muscle energy storage via the Nrf2 and IGF1/Insulin-Akt-mTOR signaling pathway. |
| first_indexed | 2024-04-13T06:49:21Z |
| format | Article |
| id | doaj.art-58b2949435124beeb7219c65bc88d26a |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T06:49:21Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-58b2949435124beeb7219c65bc88d26a2022-12-22T02:57:28ZengElsevierJournal of Functional Foods1756-46462022-12-0199105318Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged ratsPattarawadee Taengthong0Ittipon Phoungpetchara1Onrawee Khongsombat2Sakara Tunsophon3Department of Physiology, Faculty of Medical Science, Naresuan University, 65000 Phitsanulok, ThailandDepartment of Anatomy, Faculty of Medical Science, Naresuan University, 65000 Phitsanulok, ThailandDepartment of Physiology, Faculty of Medical Science, Naresuan University, 65000 Phitsanulok, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, 65000 Phitsanulok, ThailandDepartment of Physiology, Faculty of Medical Science, Naresuan University, 65000 Phitsanulok, Thailand; Center of Excellence for Innovation in Chemistry, Naresuan University, 65000 Phitsanulok, Thailand; Corresponding author at: Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9 Tahpoh, Muang, Phitsanulok 65000, Thailand.Muscle atrophy is a reduction of muscle mass and size that occurs after the age of 30. The effects of the solid dispersions of curcumin (CURSD) and gamma-oryzanol (GOSD) were investigated on skeletal muscle of middle-aged Sprague-Dawley rats (12 months old) and compared to young rats (4 months old). A mixture of CURSD and GOSD supplements (GO-CURSD) increased antioxidant enzymes through the Nrf2 pathway which caused a reduction in lipid peroxidation and pro-inflammations, resulting in less muscle damage. The GO-CURSD increased IRS1-AKT-mTOR activity and suppressed Atrogin-1 and MuRF-1 genes, resulting in increased muscle mass and cross-sectional area. In addition, the GO-CURSD increased muscular glucose uptake and glycogen via IRS1-Akt up-regulated GLUT4 expression. These results suggest that the synergistic effect of CURSD and GOSD against age-related muscle atrophy regulated by increasing the antioxidant and anti-inflammatory activities, as well as improving muscle energy storage via the Nrf2 and IGF1/Insulin-Akt-mTOR signaling pathway.http://www.sciencedirect.com/science/article/pii/S1756464622003887Muscle atrophyMiddle-aged ratsCurcumin solid dispersionGamma-oryzanol solid dispersionNrf2 pathwayIGF1/insulin-Akt-mTOR signaling pathway |
| spellingShingle | Pattarawadee Taengthong Ittipon Phoungpetchara Onrawee Khongsombat Sakara Tunsophon Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats Journal of Functional Foods Muscle atrophy Middle-aged rats Curcumin solid dispersion Gamma-oryzanol solid dispersion Nrf2 pathway IGF1/insulin-Akt-mTOR signaling pathway |
| title | Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats |
| title_full | Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats |
| title_fullStr | Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats |
| title_full_unstemmed | Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats |
| title_short | Synergistic effects of curcumin and gamma-oryzanol solid dispersions ameliorate muscle atrophy by upregulating Nrf2 and IGF1/Insulin-Akt-mTOR activities in middle-aged rats |
| title_sort | synergistic effects of curcumin and gamma oryzanol solid dispersions ameliorate muscle atrophy by upregulating nrf2 and igf1 insulin akt mtor activities in middle aged rats |
| topic | Muscle atrophy Middle-aged rats Curcumin solid dispersion Gamma-oryzanol solid dispersion Nrf2 pathway IGF1/insulin-Akt-mTOR signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003887 |
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