The Efficacy of HGF/VEGF Gene Therapy for Limb Ischemia in Mice with Impaired Glucose Tolerance: Shift from Angiogenesis to Axonal Growth and Oxidative Potential in Skeletal Muscle

The Efficacy of HGF/VEGF Gene Therapy for Limb Ischemia in Mice with Impaired Glucose Tolerance: Shift from Angiogenesis to Axonal Growth and Oxidative Potential in Skeletal Muscle

Background: Combined non-viral gene therapy (GT) of ischemia and cardiovascular disease is a promising tool for potential clinical translation. In previous studies our group has developed combined gene therapy by vascular endothelial growth factor 165 (<i>VEGF165</i>) + hepatocyte growth...

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Bibliographic Details
Main Authors: Iurii S. Stafeev I, Maria A. Boldyreva, Svetlana S. Michurina, Margarita Yu. Agareva, Arina V. Radnaeva, Mikhail Yu. Menshikov, Yu-Chen Hu, Pavel I. Makarevich, Yelena V. Parfyonova
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
gene therapy
plasmid
limb ischemia
high-fat diet
obesity
VEGF
Online Access:https://www.mdpi.com/2073-4409/11/23/3824

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