Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly
BackgroundThis study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea.MethodsDNA was extracted from the peripheral blood of 30 unrelated patients with acromegal...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2015-09-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-312.pdf |
| _version_ | 1819048119517577216 |
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| author | Hye Yoon Park In Ryang Hwang Jung Bum Seo Su Won Kim Hyun Ae Seo In Kyu Lee Jung Guk Kim |
| author_facet | Hye Yoon Park In Ryang Hwang Jung Bum Seo Su Won Kim Hyun Ae Seo In Kyu Lee Jung Guk Kim |
| author_sort | Hye Yoon Park |
| collection | DOAJ |
| description | BackgroundThis study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea.MethodsDNA was extracted from the peripheral blood of 30 unrelated patients with acromegaly. GHR genotypes were evaluated by polymerase chain reaction and correlated with demographic data and laboratory parameters.ResultsNo patient had the d3/d3 genotype, while four (13.3%) had the d3/fl genotype, and 26 (86.7%) had the fl/fl genotype. Body mass index (BMI) in patients with the d3/fl genotype was significantly higher than in those with the fl/fl genotype (P=0.001). Age, gender, blood pressure, insulin-like growth factor-1, growth hormone, fasting plasma glucose, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels showed no significant differences between the two genotypes.ConclusionThe d3-GHR polymorphism may be associated with high BMI but not with other demographic characteristics or laboratory parameters. |
| first_indexed | 2024-12-21T11:11:11Z |
| format | Article |
| id | doaj.art-58b3f2deb23747c9bb16c27ba7acf66e |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-21T11:11:11Z |
| publishDate | 2015-09-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-58b3f2deb23747c9bb16c27ba7acf66e2022-12-21T19:06:05ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782015-09-0130331231710.3803/EnM.2015.30.3.31220822Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with AcromegalyHye Yoon ParkIn Ryang HwangJung Bum SeoSu Won KimHyun Ae SeoIn Kyu LeeJung Guk KimBackgroundThis study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea.MethodsDNA was extracted from the peripheral blood of 30 unrelated patients with acromegaly. GHR genotypes were evaluated by polymerase chain reaction and correlated with demographic data and laboratory parameters.ResultsNo patient had the d3/d3 genotype, while four (13.3%) had the d3/fl genotype, and 26 (86.7%) had the fl/fl genotype. Body mass index (BMI) in patients with the d3/fl genotype was significantly higher than in those with the fl/fl genotype (P=0.001). Age, gender, blood pressure, insulin-like growth factor-1, growth hormone, fasting plasma glucose, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels showed no significant differences between the two genotypes.ConclusionThe d3-GHR polymorphism may be associated with high BMI but not with other demographic characteristics or laboratory parameters.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-312.pdfGrowth hormone receptor exon 3 deletionPolymorphismAcromegalyBody mass indexFasting plasma glucose |
| spellingShingle | Hye Yoon Park In Ryang Hwang Jung Bum Seo Su Won Kim Hyun Ae Seo In Kyu Lee Jung Guk Kim Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly Endocrinology and Metabolism Growth hormone receptor exon 3 deletion Polymorphism Acromegaly Body mass index Fasting plasma glucose |
| title | Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly |
| title_full | Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly |
| title_fullStr | Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly |
| title_full_unstemmed | Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly |
| title_short | Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly |
| title_sort | association between the growth hormone receptor exon 3 polymorphism and metabolic factors in korean patients with acromegaly |
| topic | Growth hormone receptor exon 3 deletion Polymorphism Acromegaly Body mass index Fasting plasma glucose |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-312.pdf |
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