Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy
In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy. In this study, a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy (SERS). T...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522003872 |
| _version_ | 1811154396032008192 |
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| author | Xueqin Huang Bingbing Sheng Hemi Tian Qiuxia Chen Yingqi Yang Brian Bui Jiang Pi Huaihong Cai Shanze Chen Jianglin Zhang Wei Chen Haibo Zhou Pinghua Sun |
| author_facet | Xueqin Huang Bingbing Sheng Hemi Tian Qiuxia Chen Yingqi Yang Brian Bui Jiang Pi Huaihong Cai Shanze Chen Jianglin Zhang Wei Chen Haibo Zhou Pinghua Sun |
| author_sort | Xueqin Huang |
| collection | DOAJ |
| description | In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy. In this study, a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy (SERS). The Fe3O4@Au@Ag nanoparticles (NPs) deposited graphene oxide (GO) nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid (4-MPBA) to form SERS probes (GO-Fe3O4@Au@Ag-MPBA). Furthermore, doxorubicin (DOX) is attached to SERS probes through a pH-responsive linker boronic ester (GO-Fe3O4@Au@Ag-MPBA-DOX), accompanying the 4-MPBA signal change in SERS. After the entry into tumor, the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal. Thus, the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra. Additionally, the strong T2 magnetic resonance (MR) signal and NIR photothermal transduction efficiency of the nanocomposites make it available for MR imaging and photothermal therapy (PTT). Altogether, this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting, pH-sensitive drug release, SERS-traceable detection and MR imaging, endowing it great potential for SERS/MR imaging-guided efficient chemo-phototherapy on cancer treatment. |
| first_indexed | 2024-04-10T04:14:52Z |
| format | Article |
| id | doaj.art-58b4b4ef76b449e5945cc8cb87f9092a |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-10T04:14:52Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-58b4b4ef76b449e5945cc8cb87f9092a2023-03-12T04:21:01ZengElsevierActa Pharmaceutica Sinica B2211-38352023-03-0113313031317Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapyXueqin Huang0Bingbing Sheng1Hemi Tian2Qiuxia Chen3Yingqi Yang4Brian Bui5Jiang Pi6Huaihong Cai7Shanze Chen8Jianglin Zhang9Wei Chen10Haibo Zhou11Pinghua Sun12The Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaDepartment of Physics, the University of Texas at Arlington, Arlington, TX 76019, USADepartment of Chemistry, Jinan University, Guangzhou 510632, ChinaDepartment of Chemistry, Jinan University, Guangzhou 510632, ChinaThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, ChinaDepartment of Physics, the University of Texas at Arlington, Arlington, TX 76019, USAThe Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, China; Corresponding authors.The Second Clinical Medical College (Shenzhen People’s Hospital), College of Pharmacy, Jinan University, Guangzhou, 510632, China; Corresponding authors.In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy. In this study, a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy (SERS). The Fe3O4@Au@Ag nanoparticles (NPs) deposited graphene oxide (GO) nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid (4-MPBA) to form SERS probes (GO-Fe3O4@Au@Ag-MPBA). Furthermore, doxorubicin (DOX) is attached to SERS probes through a pH-responsive linker boronic ester (GO-Fe3O4@Au@Ag-MPBA-DOX), accompanying the 4-MPBA signal change in SERS. After the entry into tumor, the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal. Thus, the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra. Additionally, the strong T2 magnetic resonance (MR) signal and NIR photothermal transduction efficiency of the nanocomposites make it available for MR imaging and photothermal therapy (PTT). Altogether, this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting, pH-sensitive drug release, SERS-traceable detection and MR imaging, endowing it great potential for SERS/MR imaging-guided efficient chemo-phototherapy on cancer treatment.http://www.sciencedirect.com/science/article/pii/S2211383522003872Surface-enhanced Raman spectroscopypH-sensitive nanoparticlesReal-time monitoringChemo-phototherapyDrug delivery systemsAnti-cancer nanotechnology |
| spellingShingle | Xueqin Huang Bingbing Sheng Hemi Tian Qiuxia Chen Yingqi Yang Brian Bui Jiang Pi Huaihong Cai Shanze Chen Jianglin Zhang Wei Chen Haibo Zhou Pinghua Sun Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy Acta Pharmaceutica Sinica B Surface-enhanced Raman spectroscopy pH-sensitive nanoparticles Real-time monitoring Chemo-phototherapy Drug delivery systems Anti-cancer nanotechnology |
| title | Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy |
| title_full | Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy |
| title_fullStr | Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy |
| title_full_unstemmed | Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy |
| title_short | Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy |
| title_sort | real time sers monitoring anticancer drug release along with sers mr imaging for ph sensitive chemo phototherapy |
| topic | Surface-enhanced Raman spectroscopy pH-sensitive nanoparticles Real-time monitoring Chemo-phototherapy Drug delivery systems Anti-cancer nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522003872 |
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