Downregulation of miR-221–3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1
Background: Gastric cancer (GC) is an aggressive gastrointestinal tumor. MiRNAs participate in the tumorigenesis of GC. Nevertheless, the function of miR-221–3p in GC remains largely unknown. Methods: RNA levels were assessed by RT-qPCR. Western blot was performed to test the protein levels. The rel...
Main Authors: | Chang-Jiang Shao, Hai-Lang Zhou, Xu-Zhu Gao, Chun-Fang Xu |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-06-01
|
Series: | Translational Oncology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523323000359 |
Similar Items
-
The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection Responses
by: Shuang Liu, et al.
Published: (2024-01-01) -
Knockdown of ATF3 suppresses the progression of ischemic stroke through inhibiting ferroptosis
by: Jin Ye, et al.
Published: (2023-01-01) -
HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression
by: Lijun Zhang, et al.
Published: (2023-12-01) -
SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3
by: Xi chen, et al.
Published: (2024-02-01) -
Bioinformatics and Integrative Experimental Method to Identifying and Validating Co-Expressed Ferroptosis-Related Genes in OA Articular Cartilage and Synovium
by: Ma J, et al.
Published: (2024-02-01)