A Case Series of Recalcitrant Pemphigus
Pemphigus consists of a group of life threatening autoimmune bullous disorders characterised by flaccid blisters and erosions of the skin and mucosal membranes of oral, laryngeal, conjunctival, pharyngeal, anal, vaginal etc. Pemphigus vulgaris involves mucosa in 50-70% of the patients. Pemphigus is...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/16084/53400_CE[Ra1]_F[SH]_PF1(SC_SS)_PFA(SS)_PN(SHU).pdf |
| _version_ | 1811170102559637504 |
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| author | Rajkumar Kannan Samuel Jayaraj Daniel Poornima Ramesh Aravamuthan |
| author_facet | Rajkumar Kannan Samuel Jayaraj Daniel Poornima Ramesh Aravamuthan |
| author_sort | Rajkumar Kannan |
| collection | DOAJ |
| description | Pemphigus consists of a group of life threatening autoimmune bullous disorders characterised by flaccid blisters and erosions of the skin and mucosal membranes of oral, laryngeal, conjunctival, pharyngeal, anal, vaginal etc. Pemphigus vulgaris involves mucosa in 50-70% of the patients. Pemphigus is associated with other autoimmune disorders like myasthenia gravis and thymoma. Primary subsets of pemphigus include pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. Pemphigus vulgaris constitutes nearly 70% of cases of pemphigus, with its antigens desmoglein 1 and 3, which are calcium dependent calmodulins, being the crucial targets for IgG1 and IgG4 classes of antibodies. If left untreated at an early stage, pemphigus vulgaris is associated with significant morbidity and mortality. The authors present a case series of five patients (34-year-old male, 68-year-old male, 52-year-old male, 74-year-old female and 65-year-old female) presenting recalcitrant pemphigus with focus on the various factors that affect the disease outcomes, morbidity and mortality. |
| first_indexed | 2024-04-10T16:52:59Z |
| format | Article |
| id | doaj.art-58b7507d96b64d52be1a4c12308e776b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T16:52:59Z |
| publishDate | 2022-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-58b7507d96b64d52be1a4c12308e776b2023-02-07T11:02:14ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-03-01163WR01WR0510.7860/JCDR/2022/53400.16084A Case Series of Recalcitrant PemphigusRajkumar Kannan0Samuel Jayaraj Daniel1Poornima2Ramesh Aravamuthan3Associate Professor, Department of Dermatology, Madras Medical College, Chennai, Tamil Nadu, India.Associate Professor, Department of Dermatology, Madras Medical College, Chennai, Tamil Nadu, India.Resident, Department of Dermatology, Madras Medical College, Chennai, Tamil Nadu, India.Professor, Department of Dermatology, Madras Medical College, Chennai, Tamil Nadu, India.Pemphigus consists of a group of life threatening autoimmune bullous disorders characterised by flaccid blisters and erosions of the skin and mucosal membranes of oral, laryngeal, conjunctival, pharyngeal, anal, vaginal etc. Pemphigus vulgaris involves mucosa in 50-70% of the patients. Pemphigus is associated with other autoimmune disorders like myasthenia gravis and thymoma. Primary subsets of pemphigus include pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. Pemphigus vulgaris constitutes nearly 70% of cases of pemphigus, with its antigens desmoglein 1 and 3, which are calcium dependent calmodulins, being the crucial targets for IgG1 and IgG4 classes of antibodies. If left untreated at an early stage, pemphigus vulgaris is associated with significant morbidity and mortality. The authors present a case series of five patients (34-year-old male, 68-year-old male, 52-year-old male, 74-year-old female and 65-year-old female) presenting recalcitrant pemphigus with focus on the various factors that affect the disease outcomes, morbidity and mortality.https://www.jcdr.net/articles/PDF/16084/53400_CE[Ra1]_F[SH]_PF1(SC_SS)_PFA(SS)_PN(SHU).pdfdeep vein thrombosispemphigus vegetansresistant pemphigussepticaemia |
| spellingShingle | Rajkumar Kannan Samuel Jayaraj Daniel Poornima Ramesh Aravamuthan A Case Series of Recalcitrant Pemphigus Journal of Clinical and Diagnostic Research deep vein thrombosis pemphigus vegetans resistant pemphigus septicaemia |
| title | A Case Series of Recalcitrant Pemphigus |
| title_full | A Case Series of Recalcitrant Pemphigus |
| title_fullStr | A Case Series of Recalcitrant Pemphigus |
| title_full_unstemmed | A Case Series of Recalcitrant Pemphigus |
| title_short | A Case Series of Recalcitrant Pemphigus |
| title_sort | case series of recalcitrant pemphigus |
| topic | deep vein thrombosis pemphigus vegetans resistant pemphigus septicaemia |
| url | https://www.jcdr.net/articles/PDF/16084/53400_CE[Ra1]_F[SH]_PF1(SC_SS)_PFA(SS)_PN(SHU).pdf |
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