Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1‐7/MasR cascade

Diminazene aceturate or losartan ameliorates the functional, radiological and histopathological alterations in knee osteoarthritis rodent model: repurposing of the ACE2/Ang1‐7/MasR cascade

Abstract Purpose Current therapies for osteoarthritis (OA) are limited to analgesics and anti‐inflammatory drugs. Considering the importance of oxidative stress and inflammatory mediators in OA etiology, we tested the hypothesis that targeting the renin–angiotensin–aldosterone system (RAAS) can impr...

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Bibliographic Details
Main Authors: Yasser H. Habib, Eman Sheta, Mahmoud Khattab, Mennatallah A. Gowayed
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Journal of Experimental Orthopaedics
Subjects:
Osteoarthritis
Oxidative stress
Inflammatory mediators
RAAS
Diminazene aceturate
Losartan
Online Access:https://doi.org/10.1186/s40634-023-00673-1

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