Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex
Noradrenaline has been shown to modulate sensory driven responses in the primary visual cortex (V1) of a number of vertebrate species. Moreover, this neurotransmitter has been postulated to bridge neuronal activation to genomic responses in order to instruct cells in long-lasting changes in neuronal...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-01-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.4137/JEN.S6497 |
| _version_ | 1818340902724173824 |
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| author | Liisa A. Tremere |
| author_facet | Liisa A. Tremere |
| author_sort | Liisa A. Tremere |
| collection | DOAJ |
| description | Noradrenaline has been shown to modulate sensory driven responses in the primary visual cortex (V1) of a number of vertebrate species. Moreover, this neurotransmitter has been postulated to bridge neuronal activation to genomic responses in order to instruct cells in long-lasting changes in neuronal performance. Here we show that local noradrenergic receptor activation in V1 is required for experience-regulated gene expression in the mouse V1. More specifically, we demonstrate that noradrenaline used locally within V1 mediates the light-driven gene expression of egr-1, an immediate early gene implicated as a mediator of neuronal plasticity. Visually-driven egr-1 expression largely depends on the α-adrenergic receptor subtype, with a lesser involvement of the β-subtype. Our findings suggest that noradrenergic transmission regulates plasticity associated gene expression in V1 of awake mice and is well positioned to broadly integrate experience-dependent changes at the cell's membrane and the genomic machinery in neurons. |
| first_indexed | 2024-12-13T15:50:17Z |
| format | Article |
| id | doaj.art-58b93dbf86e448b093992394bc2cd1c4 |
| institution | Directory Open Access Journal |
| issn | 1179-0695 |
| language | English |
| last_indexed | 2024-12-13T15:50:17Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Experimental Neuroscience |
| spelling | doaj.art-58b93dbf86e448b093992394bc2cd1c42022-12-21T23:39:32ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952011-01-01510.4137/JEN.S6497Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual CortexLiisa A. Tremere0Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA. Department of geriatric Medicine and ROCA University of Oklahoma Health Sciences Center Oklahoma City, OK 73104-0505.Noradrenaline has been shown to modulate sensory driven responses in the primary visual cortex (V1) of a number of vertebrate species. Moreover, this neurotransmitter has been postulated to bridge neuronal activation to genomic responses in order to instruct cells in long-lasting changes in neuronal performance. Here we show that local noradrenergic receptor activation in V1 is required for experience-regulated gene expression in the mouse V1. More specifically, we demonstrate that noradrenaline used locally within V1 mediates the light-driven gene expression of egr-1, an immediate early gene implicated as a mediator of neuronal plasticity. Visually-driven egr-1 expression largely depends on the α-adrenergic receptor subtype, with a lesser involvement of the β-subtype. Our findings suggest that noradrenergic transmission regulates plasticity associated gene expression in V1 of awake mice and is well positioned to broadly integrate experience-dependent changes at the cell's membrane and the genomic machinery in neurons.https://doi.org/10.4137/JEN.S6497 |
| spellingShingle | Liisa A. Tremere Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex Journal of Experimental Neuroscience |
| title | Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex |
| title_full | Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex |
| title_fullStr | Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex |
| title_full_unstemmed | Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex |
| title_short | Noradrenergic Modulation of Light-Driven Egr-1 Expression in the Adult Visual Cortex |
| title_sort | noradrenergic modulation of light driven egr 1 expression in the adult visual cortex |
| url | https://doi.org/10.4137/JEN.S6497 |
| work_keys_str_mv | AT liisaatremere noradrenergicmodulationoflightdrivenegr1expressionintheadultvisualcortex |