Stem Cell Quiescence versus Senescence: The Key for Healthy Aging
BACKGROUND: Aging tissues lose their homeostatic and regenerative capacities, which has been linked to the degeneration of the stem cells such as the tissue-specific stem cells, the stem cell niches, and systemic cues that regulate stem cell activity. CONTENT: The maintenance of tissue homeostatic...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2021-12-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/1655 |
| _version_ | 1819173869488963584 |
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| author | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya |
| author_facet | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya |
| author_sort | Anna Meiliana |
| collection | DOAJ |
| description | BACKGROUND: Aging tissues lose their homeostatic and regenerative capacities, which has been linked to the degeneration of the stem cells such as the tissue-specific stem cells, the stem cell niches, and systemic cues that regulate stem cell activity.
CONTENT: The maintenance of tissue homeostatic and regeneration dependent on its tissue-specific stem cells, that —long-lived cells with the ability to self-renew and differentiate into mature cells. Understanding the molecular mechanisms that governs stem cell survival, self-renewal, quiescence, proliferation, and commitment to specific differentiated cell lineages is critical for identifying the drivers and effectors of age-associated stem cell failure. Such understanding will be critical for the development of therapeutic approaches that can decrease, and possibly reverse and repair the age-related degenerative process in aging tissues.
SUMMARY: The exact mechanisms and reasons of aging process were not fully elucidated until now. Stem cells is one of the keys for maintaining tissues heath and understanding how stem cell decline with age will give us opportunities to find strategy in increasing somatic stem cells regenerative capacity and delay the aging process.
KEYWORDS: adult stem cell, aging, epigenetic, metabolism, quiescence, senescence |
| first_indexed | 2024-12-22T20:29:56Z |
| format | Article |
| id | doaj.art-58bc4f298bbd4562aabb2a09540499ad |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-12-22T20:29:56Z |
| publishDate | 2021-12-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-58bc4f298bbd4562aabb2a09540499ad2022-12-21T18:13:38ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792021-12-011343374910.18585/inabj.v13i4.1655427Stem Cell Quiescence versus Senescence: The Key for Healthy AgingAnna Meiliana0Nurrani Mustika Dewi1Andi Wijaya2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363Prodia Clinical Laboratory, Jl. Kramat Raya No.150, Jakarta 10430Prodia Clinical Laboratory, Jl. Supratman No 43, Bandung 40114BACKGROUND: Aging tissues lose their homeostatic and regenerative capacities, which has been linked to the degeneration of the stem cells such as the tissue-specific stem cells, the stem cell niches, and systemic cues that regulate stem cell activity. CONTENT: The maintenance of tissue homeostatic and regeneration dependent on its tissue-specific stem cells, that —long-lived cells with the ability to self-renew and differentiate into mature cells. Understanding the molecular mechanisms that governs stem cell survival, self-renewal, quiescence, proliferation, and commitment to specific differentiated cell lineages is critical for identifying the drivers and effectors of age-associated stem cell failure. Such understanding will be critical for the development of therapeutic approaches that can decrease, and possibly reverse and repair the age-related degenerative process in aging tissues. SUMMARY: The exact mechanisms and reasons of aging process were not fully elucidated until now. Stem cells is one of the keys for maintaining tissues heath and understanding how stem cell decline with age will give us opportunities to find strategy in increasing somatic stem cells regenerative capacity and delay the aging process. KEYWORDS: adult stem cell, aging, epigenetic, metabolism, quiescence, senescencehttps://inabj.org/index.php/ibj/article/view/1655 |
| spellingShingle | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya Stem Cell Quiescence versus Senescence: The Key for Healthy Aging Indonesian Biomedical Journal |
| title | Stem Cell Quiescence versus Senescence: The Key for Healthy Aging |
| title_full | Stem Cell Quiescence versus Senescence: The Key for Healthy Aging |
| title_fullStr | Stem Cell Quiescence versus Senescence: The Key for Healthy Aging |
| title_full_unstemmed | Stem Cell Quiescence versus Senescence: The Key for Healthy Aging |
| title_short | Stem Cell Quiescence versus Senescence: The Key for Healthy Aging |
| title_sort | stem cell quiescence versus senescence the key for healthy aging |
| url | https://inabj.org/index.php/ibj/article/view/1655 |
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