Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease
The disease progression of severe alcohol-related cognitive impairment (ARCI) is debated. The aim of this study was to compare the cognitive change of patients with severe ARCI in inpatient setting to that of patients with Alzheimer’s disease (AD). Fifteen consecutive patients with severe ARCI were...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.936639/full |
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| author | Virgile Clergue-Duval Virgile Clergue-Duval Virgile Clergue-Duval Virgile Clergue-Duval Thomas Barré Thomas Barré Emmanuel Cognat Emmanuel Cognat Emmanuel Cognat Anne-Laure Brichet Anne-Laure Brichet Claire Géraud Claire Géraud Julien Azuar Julien Azuar Julien Azuar Philippe Michaud Philippe Michaud Dorothée Lecallier Dorothée Lecallier Sonia Arfaoui-Geffroy Sonia Arfaoui-Geffroy Eric Hispard Eric Hispard Claire Paquet Claire Paquet Claire Paquet Frank Bellivier Frank Bellivier Frank Bellivier Frank Questel Frank Questel Frank Questel Florence Vorspan Florence Vorspan Florence Vorspan all members of the ResAlCog care network |
| author_facet | Virgile Clergue-Duval Virgile Clergue-Duval Virgile Clergue-Duval Virgile Clergue-Duval Thomas Barré Thomas Barré Emmanuel Cognat Emmanuel Cognat Emmanuel Cognat Anne-Laure Brichet Anne-Laure Brichet Claire Géraud Claire Géraud Julien Azuar Julien Azuar Julien Azuar Philippe Michaud Philippe Michaud Dorothée Lecallier Dorothée Lecallier Sonia Arfaoui-Geffroy Sonia Arfaoui-Geffroy Eric Hispard Eric Hispard Claire Paquet Claire Paquet Claire Paquet Frank Bellivier Frank Bellivier Frank Bellivier Frank Questel Frank Questel Frank Questel Florence Vorspan Florence Vorspan Florence Vorspan all members of the ResAlCog care network |
| author_sort | Virgile Clergue-Duval |
| collection | DOAJ |
| description | The disease progression of severe alcohol-related cognitive impairment (ARCI) is debated. The aim of this study was to compare the cognitive change of patients with severe ARCI in inpatient setting to that of patients with Alzheimer’s disease (AD). Fifteen consecutive patients with severe ARCI were recruited between 2013 and 2015. They received inpatient detoxification, neurological assessment, and inpatient cognitive rehabilitation in specialized facilities. Twelve patients, with documented AD matched on sex and initial cognitive impairment severity, were selected. All have benefited from two neuropsychological assessments. The neurocognitive change was tested in both groups with pair-wised Wilcoxon tests. ARCI and AD patients’ time course was compared with Mann–Whitney–Wilcoxon test. In ARCI group, first assessment occurred at 2.9 (± 2.2) months of abstinence and follow-up 6.5 (± 2.9) months later, the mean age was 56.5 (± 7.4) years, and 12 were men. In AD group, follow-up occurred at 12.8 (± 2.9) months (p < 10–3), the mean age was 72.3 (± 8.4) years (p < 10–3), and 10 were men. ARCI patients significantly improved on one executive function test (TMT-B; p < 0.05), while AD patients have worsened memory subtests on Free-and-Cued-Selective-Reminding Test (p < 0.05). These tests showed a statistically different change between severe ARCI and AD group (p < 0.05). Severe ARCI patients have improved in executive functioning, discernible on the TMT-B test, in specific care setting, including abstinence maintenance and rehabilitation. The disease progression was different from that observed in AD patients. |
| first_indexed | 2024-04-12T09:36:40Z |
| format | Article |
| id | doaj.art-58bda51a486341aea247ce4568c4215b |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-12T09:36:40Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-58bda51a486341aea247ce4568c4215b2022-12-22T03:38:12ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-07-011310.3389/fpsyg.2022.936639936639Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s DiseaseVirgile Clergue-Duval0Virgile Clergue-Duval1Virgile Clergue-Duval2Virgile Clergue-Duval3Thomas Barré4Thomas Barré5Emmanuel Cognat6Emmanuel Cognat7Emmanuel Cognat8Anne-Laure Brichet9Anne-Laure Brichet10Claire Géraud11Claire Géraud12Julien Azuar13Julien Azuar14Julien Azuar15Philippe Michaud16Philippe Michaud17Dorothée Lecallier18Dorothée Lecallier19Sonia Arfaoui-Geffroy20Sonia Arfaoui-Geffroy21Eric Hispard22Eric Hispard23Claire Paquet24Claire Paquet25Claire Paquet26Frank Bellivier27Frank Bellivier28Frank Bellivier29Frank Questel30Frank Questel31Frank Questel32Florence Vorspan33Florence Vorspan34Florence Vorspan35all members of the ResAlCog care networkDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceUFR de Médecine, Université Paris Cité, Paris, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceUFR de Médecine, Université Paris Cité, Paris, FranceCentre de Neurologie Cognitive, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceClinique des Epinettes, Paris, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceUnité Serge Korsakoff-Maison d’Accueil Spécialisée, Villeneuve-la-Garenne, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceClinique des Epinettes, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceClinique Médicale du Parc, Saint-Ouen-l'Aumône, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceUFR de Médecine, Université Paris Cité, Paris, FranceCentre de Neurologie Cognitive, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceUFR de Médecine, Université Paris Cité, Paris, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceResAlCog (Réseau Pour la Prise en Charge des Troubles Cognitifs Liés à L’alcool), Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceDépartement de Psychiatrie et de Médecine Addictologique, Site Lariboisière Fernand-Widal, GHU APHP. Nord - Université Paris Cité, APHP, Paris, FranceInserm UMRS-1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, Paris, FranceUFR de Médecine, Université Paris Cité, Paris, FranceThe disease progression of severe alcohol-related cognitive impairment (ARCI) is debated. The aim of this study was to compare the cognitive change of patients with severe ARCI in inpatient setting to that of patients with Alzheimer’s disease (AD). Fifteen consecutive patients with severe ARCI were recruited between 2013 and 2015. They received inpatient detoxification, neurological assessment, and inpatient cognitive rehabilitation in specialized facilities. Twelve patients, with documented AD matched on sex and initial cognitive impairment severity, were selected. All have benefited from two neuropsychological assessments. The neurocognitive change was tested in both groups with pair-wised Wilcoxon tests. ARCI and AD patients’ time course was compared with Mann–Whitney–Wilcoxon test. In ARCI group, first assessment occurred at 2.9 (± 2.2) months of abstinence and follow-up 6.5 (± 2.9) months later, the mean age was 56.5 (± 7.4) years, and 12 were men. In AD group, follow-up occurred at 12.8 (± 2.9) months (p < 10–3), the mean age was 72.3 (± 8.4) years (p < 10–3), and 10 were men. ARCI patients significantly improved on one executive function test (TMT-B; p < 0.05), while AD patients have worsened memory subtests on Free-and-Cued-Selective-Reminding Test (p < 0.05). These tests showed a statistically different change between severe ARCI and AD group (p < 0.05). Severe ARCI patients have improved in executive functioning, discernible on the TMT-B test, in specific care setting, including abstinence maintenance and rehabilitation. The disease progression was different from that observed in AD patients.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.936639/fullalcohol-related cognitive impairmentalcohol brain damagealcohol use disorderAlzheimer’s diseasecognitive impairmentdisease progression |
| spellingShingle | Virgile Clergue-Duval Virgile Clergue-Duval Virgile Clergue-Duval Virgile Clergue-Duval Thomas Barré Thomas Barré Emmanuel Cognat Emmanuel Cognat Emmanuel Cognat Anne-Laure Brichet Anne-Laure Brichet Claire Géraud Claire Géraud Julien Azuar Julien Azuar Julien Azuar Philippe Michaud Philippe Michaud Dorothée Lecallier Dorothée Lecallier Sonia Arfaoui-Geffroy Sonia Arfaoui-Geffroy Eric Hispard Eric Hispard Claire Paquet Claire Paquet Claire Paquet Frank Bellivier Frank Bellivier Frank Bellivier Frank Questel Frank Questel Frank Questel Florence Vorspan Florence Vorspan Florence Vorspan all members of the ResAlCog care network Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease Frontiers in Psychology alcohol-related cognitive impairment alcohol brain damage alcohol use disorder Alzheimer’s disease cognitive impairment disease progression |
| title | Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease |
| title_full | Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease |
| title_fullStr | Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease |
| title_full_unstemmed | Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease |
| title_short | Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease |
| title_sort | patients with severe alcohol related cognitive impairment improve in flexibility when abstinence is maintained a comparative study with alzheimer s disease |
| topic | alcohol-related cognitive impairment alcohol brain damage alcohol use disorder Alzheimer’s disease cognitive impairment disease progression |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.936639/full |
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