Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

We generated two IgG1-like bispecific antibodies (BsAbs) with different molecular formats, symmetrical DVD-Ig and asymmetrical knob-in-hole (KIH), targeting the same antigens, EGFR and PD-L1 (designated as anti-EGFR/PD-L1). We performed the physiochemical and biological characterization of these two...

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Bibliographic Details
Main Authors: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L. Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S. Rotstein, Lorraine C. Pelosof, Wen Jin Wu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
bispecific antibodies (BsAbs)
EFGR
PD-L1
triple-negative breast cancer (TNBC)
bioassays
Online Access:https://www.mdpi.com/1999-4923/14/7/1381

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