Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury

Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury

Neuropathic pain, an intractable pain symptom that occurs after nerve damage, is caused by the aberrant excitability of spinal dorsal horn (SDH) neurons. Gabapentinoids, the most commonly used drugs for neuropathic pain, inhibit spinal calcium-mediated neurotransmitter release by binding to α2δ-1, a...

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Bibliographic Details
Main Authors: Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Kazufumi Kubota, Yutaka Kitano, Hidemasa Furue
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal cord
neuropathic pain
α2δ-1
synaptic transmission
gabapentinoid
disinhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1099925/full

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