Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms
Atrial fibrillation (AF) is associated with cognitive impairment, with or without history of stroke. The risk of developing cognitive impairment is increased after clinical stroke. Prospective registries confirm the increased risk of both vascular and Alzheimer's dementia in patients with AF. T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Heart and Mind |
| Subjects: | |
| Online Access: | http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2024;volume=8;issue=2;spage=100;epage=110;aulast=Agarwal |
| _version_ | 1797246449551933440 |
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| author | Rakesh Agarwal Phillip J Tully Rajiv Mahajan |
| author_facet | Rakesh Agarwal Phillip J Tully Rajiv Mahajan |
| author_sort | Rakesh Agarwal |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is associated with cognitive impairment, with or without history of stroke. The risk of developing cognitive impairment is increased after clinical stroke. Prospective registries confirm the increased risk of both vascular and Alzheimer's dementia in patients with AF. The purported mechanistic links between AF and cognitive impairment are clinical stroke, subclinical cerebral small-vessel disease, autonomic dysfunction, and systemic and neuroinflammation. Several shared risk factors and genetics also contribute to this interplay. In this review, we explore the evidence bridging cognitive impairment with AF and review the mechanisms and therapeutic targets. |
| first_indexed | 2024-04-24T19:42:59Z |
| format | Article |
| id | doaj.art-58bff4e18bcf44e6bd3705ead3d1f176 |
| institution | Directory Open Access Journal |
| issn | 2468-6476 2468-6484 |
| language | English |
| last_indexed | 2024-04-24T19:42:59Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Heart and Mind |
| spelling | doaj.art-58bff4e18bcf44e6bd3705ead3d1f1762024-03-25T10:27:40ZengWolters Kluwer Medknow PublicationsHeart and Mind2468-64762468-64842024-01-018210011010.4103/hm.HM-D-23-00075Cognitive function in atrial fibrillation: A narrative review of evidence and mechanismsRakesh AgarwalPhillip J TullyRajiv MahajanAtrial fibrillation (AF) is associated with cognitive impairment, with or without history of stroke. The risk of developing cognitive impairment is increased after clinical stroke. Prospective registries confirm the increased risk of both vascular and Alzheimer's dementia in patients with AF. The purported mechanistic links between AF and cognitive impairment are clinical stroke, subclinical cerebral small-vessel disease, autonomic dysfunction, and systemic and neuroinflammation. Several shared risk factors and genetics also contribute to this interplay. In this review, we explore the evidence bridging cognitive impairment with AF and review the mechanisms and therapeutic targets.http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2024;volume=8;issue=2;spage=100;epage=110;aulast=Agarwalatrial fibrillationcognitive impairmentdementianeurocognitive disordersubclinical infarction |
| spellingShingle | Rakesh Agarwal Phillip J Tully Rajiv Mahajan Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms Heart and Mind atrial fibrillation cognitive impairment dementia neurocognitive disorder subclinical infarction |
| title | Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms |
| title_full | Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms |
| title_fullStr | Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms |
| title_full_unstemmed | Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms |
| title_short | Cognitive function in atrial fibrillation: A narrative review of evidence and mechanisms |
| title_sort | cognitive function in atrial fibrillation a narrative review of evidence and mechanisms |
| topic | atrial fibrillation cognitive impairment dementia neurocognitive disorder subclinical infarction |
| url | http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2024;volume=8;issue=2;spage=100;epage=110;aulast=Agarwal |
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