Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

Methylene blue is an FDA approved compound with a variety of pharmacologic activities. It inhibits aggregation of several amyloidogenic proteins known to be deposited in neurodegenerative diseases. Recently, it has been proposed that methylene blue shows significant beneficial effects in a phase 2 c...

Full description

Bibliographic Details
Main Authors: Frauke van Bebber, Dominik Paquet, Alexander Hruscha, Bettina Schmid, Christian Haass
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000951