Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report
Abstract Background Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may present an initial clinical behavior...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03722-y |
| _version_ | 1811175811586195456 |
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| author | Alejandro Pineda Isaza Santiago Castaño Quintero Lisceth Paola Quintero González Fabián Emiliano Ahumada Córdoba Andrés Felipe Arbeláez Olivar Juan Carlos Bravo Ocaña |
| author_facet | Alejandro Pineda Isaza Santiago Castaño Quintero Lisceth Paola Quintero González Fabián Emiliano Ahumada Córdoba Andrés Felipe Arbeláez Olivar Juan Carlos Bravo Ocaña |
| author_sort | Alejandro Pineda Isaza |
| collection | DOAJ |
| description | Abstract Background Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may present an initial clinical behavior of myeloproliferation and be characterized by varied genetic rearrangements. One of these entities is associated with FGFR1 rearrangements, characterized by its low prevalence and few treatment options. Case presentation We present the case of a 53-year-old Mestizo male patient of Hispanic origin who initially presented weight loss and fatigue, with a complete blood count showing leukocytosis and eosinophilia, with an initial diagnosis of nonspecific myeloproliferative disorder. In a next-generation sequencing study, BCR::FGFR1 rearrangement was documented, a diagnosis of myeloid/lymphoid neoplasia with eosinophilia and BCR::FGFR1 rearrangement was made, and hydroxyurea therapy was initiated. Subsequently, transformation to cortical T-lymphoblastic leukemia/lymphoma and erythroid precursors was documented, requiring management with chemotherapy. Conclusions Myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangements constitute a group of deeply heterogeneous diseases with variable clinical and diagnostic characteristics and whose treatment is not clearly defined. |
| first_indexed | 2024-04-10T19:43:01Z |
| format | Article |
| id | doaj.art-58c5b20eeb714b1590f8d3478d41702b |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-10T19:43:01Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-58c5b20eeb714b1590f8d3478d41702b2023-01-29T12:13:22ZengBMCJournal of Medical Case Reports1752-19472023-01-011711510.1186/s13256-022-03722-yMyeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case reportAlejandro Pineda Isaza0Santiago Castaño Quintero1Lisceth Paola Quintero González2Fabián Emiliano Ahumada Córdoba3Andrés Felipe Arbeláez Olivar4Juan Carlos Bravo Ocaña5Health Sciences Department, Universidad IcesiHealth Sciences Department, Universidad IcesiHealth Sciences Department, Universidad IcesiHaemato-Oncology Service, Internal Medicine Department, Fundación Valle del LiliHaemato-Oncology Service, Internal Medicine Department, Fundación Valle del LiliPathology Service, Pathology and Laboratory Department, Fundación Valle del LiliAbstract Background Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may present an initial clinical behavior of myeloproliferation and be characterized by varied genetic rearrangements. One of these entities is associated with FGFR1 rearrangements, characterized by its low prevalence and few treatment options. Case presentation We present the case of a 53-year-old Mestizo male patient of Hispanic origin who initially presented weight loss and fatigue, with a complete blood count showing leukocytosis and eosinophilia, with an initial diagnosis of nonspecific myeloproliferative disorder. In a next-generation sequencing study, BCR::FGFR1 rearrangement was documented, a diagnosis of myeloid/lymphoid neoplasia with eosinophilia and BCR::FGFR1 rearrangement was made, and hydroxyurea therapy was initiated. Subsequently, transformation to cortical T-lymphoblastic leukemia/lymphoma and erythroid precursors was documented, requiring management with chemotherapy. Conclusions Myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangements constitute a group of deeply heterogeneous diseases with variable clinical and diagnostic characteristics and whose treatment is not clearly defined.https://doi.org/10.1186/s13256-022-03722-yMyeloid/lymphoid neoplasmsPrecursor T-cell lymphoblastic leukemia–lymphomaEosinophiliaFGFR1 rearrangement |
| spellingShingle | Alejandro Pineda Isaza Santiago Castaño Quintero Lisceth Paola Quintero González Fabián Emiliano Ahumada Córdoba Andrés Felipe Arbeláez Olivar Juan Carlos Bravo Ocaña Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report Journal of Medical Case Reports Myeloid/lymphoid neoplasms Precursor T-cell lymphoblastic leukemia–lymphoma Eosinophilia FGFR1 rearrangement |
| title | Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report |
| title_full | Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report |
| title_fullStr | Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report |
| title_full_unstemmed | Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report |
| title_short | Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report |
| title_sort | myeloid lymphoid neoplasm with eosinophilia and bcr fgfr1 rearrangement with transformation to cortical t lymphoblastic lymphoma and erythroid precursors a case report |
| topic | Myeloid/lymphoid neoplasms Precursor T-cell lymphoblastic leukemia–lymphoma Eosinophilia FGFR1 rearrangement |
| url | https://doi.org/10.1186/s13256-022-03722-y |
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