Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease

Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 co...

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Bibliographic Details
Main Authors: Virginia Boccardi, Eric Westman, Luca Pelini, Olof Lindberg, J-Sebastian Muehlboeck, Andrew Simmons, Roberto Tarducci, Piero Floridi, Pietro Chiarini, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Bruno Vellas, Christian Spenger, Lars-Olof Wahlund, Simon Lovestone, Patrizia Mecocci
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
aging
Alzheimer’s disease
mild cognitive impairment
inflammation
inflammatory markers
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00439/full
Description
Summary:Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay.Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD.Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.
ISSN:1663-4365

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