Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease
Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 co...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00439/full |
| _version_ | 1819088048993861632 |
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| author | Virginia Boccardi Eric Westman Luca Pelini Olof Lindberg J-Sebastian Muehlboeck Andrew Simmons Roberto Tarducci Piero Floridi Pietro Chiarini Hilkka Soininen Iwona Kloszewska Magda Tsolaki Bruno Vellas Christian Spenger Lars-Olof Wahlund Simon Lovestone Patrizia Mecocci |
| author_facet | Virginia Boccardi Eric Westman Luca Pelini Olof Lindberg J-Sebastian Muehlboeck Andrew Simmons Roberto Tarducci Piero Floridi Pietro Chiarini Hilkka Soininen Iwona Kloszewska Magda Tsolaki Bruno Vellas Christian Spenger Lars-Olof Wahlund Simon Lovestone Patrizia Mecocci |
| author_sort | Virginia Boccardi |
| collection | DOAJ |
| description | Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay.Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD.Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration. |
| first_indexed | 2024-12-21T21:45:51Z |
| format | Article |
| id | doaj.art-58c76b47b14e47709bcd6c1dea3b5e69 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-21T21:45:51Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-58c76b47b14e47709bcd6c1dea3b5e692022-12-21T18:49:14ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-01-011010.3389/fnagi.2018.00439425698Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s DiseaseVirginia Boccardi0Eric Westman1Luca Pelini2Olof Lindberg3J-Sebastian Muehlboeck4Andrew Simmons5Roberto Tarducci6Piero Floridi7Pietro Chiarini8Hilkka Soininen9Iwona Kloszewska10Magda Tsolaki11Bruno Vellas12Christian Spenger13Lars-Olof Wahlund14Simon Lovestone15Patrizia Mecocci16Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, ItalyDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenDepartment of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, ItalyDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United KingdomDivision of Medical Physics, Perugia University Hospital, Perugia, ItalyDivision of Neuroradiology, Perugia University Hospital, Perugia, ItalyDivision of Neuroradiology, Perugia University Hospital, Perugia, ItalyDepartment of Neurology, University of Eastern Finland – Kuopio University Hospital, Kuopio, FinlandDepartment of Old Age Psychiatry and Psychotic Disorders, Medical University of Łódź, Łódź, Poland3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, GreeceUniversity of Toulouse, INSERM 1027, Gérontopôle, Toulouse, France0Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, SwedenDivision of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden1Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United KingdomDepartment of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, ItalyBackground/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay.Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD.Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.https://www.frontiersin.org/article/10.3389/fnagi.2018.00439/fullagingAlzheimer’s diseasemild cognitive impairmentinflammationinflammatory markers |
| spellingShingle | Virginia Boccardi Eric Westman Luca Pelini Olof Lindberg J-Sebastian Muehlboeck Andrew Simmons Roberto Tarducci Piero Floridi Pietro Chiarini Hilkka Soininen Iwona Kloszewska Magda Tsolaki Bruno Vellas Christian Spenger Lars-Olof Wahlund Simon Lovestone Patrizia Mecocci Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease Frontiers in Aging Neuroscience aging Alzheimer’s disease mild cognitive impairment inflammation inflammatory markers |
| title | Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease |
| title_full | Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease |
| title_fullStr | Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease |
| title_full_unstemmed | Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease |
| title_short | Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease |
| title_sort | differential associations of il 4 with hippocampal subfields in mild cognitive impairment and alzheimer s disease |
| topic | aging Alzheimer’s disease mild cognitive impairment inflammation inflammatory markers |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00439/full |
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