Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications
Abstract DNA has been used as a robust material for the building of a variety of nanoscale structures and devices owing to its unique properties. Structural DNA nanotechnology has reported a wide range of applications including computing, photonics, synthetic biology, biosensing, bioimaging, and the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202302021 |
| _version_ | 1827859561708519424 |
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| author | Huating Kong Bo Sun Feng Yu Qisheng Wang Kai Xia Dawei Jiang |
| author_facet | Huating Kong Bo Sun Feng Yu Qisheng Wang Kai Xia Dawei Jiang |
| author_sort | Huating Kong |
| collection | DOAJ |
| description | Abstract DNA has been used as a robust material for the building of a variety of nanoscale structures and devices owing to its unique properties. Structural DNA nanotechnology has reported a wide range of applications including computing, photonics, synthetic biology, biosensing, bioimaging, and therapeutic delivery, among others. Nevertheless, the foundational goal of structural DNA nanotechnology is exploiting DNA molecules to build three‐dimensional crystals as periodic molecular scaffolds to precisely align, obtain, or collect desired guest molecules. Over the past 30 years, a series of 3D DNA crystals have been rationally designed and developed. This review aims to showcase various 3D DNA crystals, their design, optimization, applications, and the crystallization conditions utilized. Additionally, the history of nucleic acid crystallography and potential future directions for 3D DNA crystals in the era of nanotechnology are discussed. |
| first_indexed | 2024-03-12T13:10:13Z |
| format | Article |
| id | doaj.art-58c8265cbbec4e4c9332f7c9211f07a6 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T13:10:13Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-58c8265cbbec4e4c9332f7c9211f07a62023-08-28T03:36:35ZengWileyAdvanced Science2198-38442023-08-011024n/an/a10.1002/advs.202302021Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and ApplicationsHuating Kong0Bo Sun1Feng Yu2Qisheng Wang3Kai Xia4Dawei Jiang5Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai201204ChinaShanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai201204ChinaShanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai201204ChinaShanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai201204ChinaShanghai Frontier Innovation Research Institute Shanghai201108ChinaWuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan430022ChinaAbstract DNA has been used as a robust material for the building of a variety of nanoscale structures and devices owing to its unique properties. Structural DNA nanotechnology has reported a wide range of applications including computing, photonics, synthetic biology, biosensing, bioimaging, and therapeutic delivery, among others. Nevertheless, the foundational goal of structural DNA nanotechnology is exploiting DNA molecules to build three‐dimensional crystals as periodic molecular scaffolds to precisely align, obtain, or collect desired guest molecules. Over the past 30 years, a series of 3D DNA crystals have been rationally designed and developed. This review aims to showcase various 3D DNA crystals, their design, optimization, applications, and the crystallization conditions utilized. Additionally, the history of nucleic acid crystallography and potential future directions for 3D DNA crystals in the era of nanotechnology are discussed.https://doi.org/10.1002/advs.202302021DNA crystallizationDNA nanotechnologyframework nucleic acidnucleic acid crystallography |
| spellingShingle | Huating Kong Bo Sun Feng Yu Qisheng Wang Kai Xia Dawei Jiang Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications Advanced Science DNA crystallization DNA nanotechnology framework nucleic acid nucleic acid crystallography |
| title | Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications |
| title_full | Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications |
| title_fullStr | Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications |
| title_full_unstemmed | Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications |
| title_short | Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications |
| title_sort | exploring the potential of three dimensional dna crystals in nanotechnology design optimization and applications |
| topic | DNA crystallization DNA nanotechnology framework nucleic acid nucleic acid crystallography |
| url | https://doi.org/10.1002/advs.202302021 |
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