18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma
BackgroundPulmonary sarcomatoid carcinoma (PSC) is a rare highly aggressive and poorly differentiated non-small cell carcinoma, and little is known about the information on the usefulness of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). We investigated t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1334156/full |
| _version_ | 1797310779887714304 |
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| author | Zhe-Huang Luo Xiao-Yan Luo Wan-Ling Qi Qian Liu |
| author_facet | Zhe-Huang Luo Xiao-Yan Luo Wan-Ling Qi Qian Liu |
| author_sort | Zhe-Huang Luo |
| collection | DOAJ |
| description | BackgroundPulmonary sarcomatoid carcinoma (PSC) is a rare highly aggressive and poorly differentiated non-small cell carcinoma, and little is known about the information on the usefulness of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). We investigated the clinical and 18F-FDG PET/CT features of PSC.MethodsWe retrospectively analyzed 25 consecutive PSC patients who had undergone 18F-FDG PET/CT. Demographic data, PET/CT findings before treatment, pathological features, and prognosis in these patients were investigated to define correlates between maximal standard uptake value (SUVmax) and clinicopathological parameters.ResultsFrom March 2017 to January 2023, twenty-five eligible patients with PSC were identified. There were 23 (92%) men, aged 68.5 ± 8.5 (range 56-90) years. Eighteen (72%) patients had a frequent smoking history. The mean size of PSCs was 59.3 ± 18.6 (range 29-97) mm, and 23 (92%) PSCs were Stage IV tumors. 20 (80%) lesions were located in the upper lung and 19 (76%) cases belonged to the peripheral type. Necrotic foci appeared in 21(84%) tumors. 11 (44%) PSCs invaded the pleura. All PSCs were FDG avid, and the mean of SUVmax was 11.8 ± 5.3 (range 4.8-25.5). Metastases were found on PET/CT in 24(96%) patients. The SUVmax of the lesions ≥ 5cm was higher than that of the lesions < 5cm (p=0.004), and the SUVmax of lesions with TTF-1 expression was higher than those of lesions without TTF-1 expression (p=0.009). All of the 25 primary lesions were considered malignant and confirmative, probable, and possible diagnosis of PSC was made in 2 (8%), 4 (16%), and 5(20%) patients, respectively on PET/CT. PSC was not considered in 14 (56%) patients, in PET/CT. The survival of patients with surgery didn’t demonstrate a significantly good prognosis as compared with those without surgery (p=0.675).ConclusionAll PSCs had obvious FDG avidity. Although imaging diagnosis is still difficult, combined clinical and imaging features more than 40% of primary lesions were considered for the possibility of PSC in our group. Early histopathological diagnosis is necessary to help develop a reasonable regimen. |
| first_indexed | 2024-03-08T01:48:55Z |
| format | Article |
| id | doaj.art-58ca82e22df3463b82e79809e35a9df5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T01:48:55Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-58ca82e22df3463b82e79809e35a9df52024-02-14T11:48:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.1334156133415618F-FDG PET/CT imaging in pulmonary sarcomatoid carcinomaZhe-Huang Luo0Xiao-Yan Luo1Wan-Ling Qi2Qian Liu3Department of Nuclear Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Clinical Laboratory, Jiangxi Provincial Children’s Hospital, The Affiliated Children’s Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Nuclear Medicine, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaDepartment of Pathology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, ChinaBackgroundPulmonary sarcomatoid carcinoma (PSC) is a rare highly aggressive and poorly differentiated non-small cell carcinoma, and little is known about the information on the usefulness of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). We investigated the clinical and 18F-FDG PET/CT features of PSC.MethodsWe retrospectively analyzed 25 consecutive PSC patients who had undergone 18F-FDG PET/CT. Demographic data, PET/CT findings before treatment, pathological features, and prognosis in these patients were investigated to define correlates between maximal standard uptake value (SUVmax) and clinicopathological parameters.ResultsFrom March 2017 to January 2023, twenty-five eligible patients with PSC were identified. There were 23 (92%) men, aged 68.5 ± 8.5 (range 56-90) years. Eighteen (72%) patients had a frequent smoking history. The mean size of PSCs was 59.3 ± 18.6 (range 29-97) mm, and 23 (92%) PSCs were Stage IV tumors. 20 (80%) lesions were located in the upper lung and 19 (76%) cases belonged to the peripheral type. Necrotic foci appeared in 21(84%) tumors. 11 (44%) PSCs invaded the pleura. All PSCs were FDG avid, and the mean of SUVmax was 11.8 ± 5.3 (range 4.8-25.5). Metastases were found on PET/CT in 24(96%) patients. The SUVmax of the lesions ≥ 5cm was higher than that of the lesions < 5cm (p=0.004), and the SUVmax of lesions with TTF-1 expression was higher than those of lesions without TTF-1 expression (p=0.009). All of the 25 primary lesions were considered malignant and confirmative, probable, and possible diagnosis of PSC was made in 2 (8%), 4 (16%), and 5(20%) patients, respectively on PET/CT. PSC was not considered in 14 (56%) patients, in PET/CT. The survival of patients with surgery didn’t demonstrate a significantly good prognosis as compared with those without surgery (p=0.675).ConclusionAll PSCs had obvious FDG avidity. Although imaging diagnosis is still difficult, combined clinical and imaging features more than 40% of primary lesions were considered for the possibility of PSC in our group. Early histopathological diagnosis is necessary to help develop a reasonable regimen.https://www.frontiersin.org/articles/10.3389/fonc.2024.1334156/fullpulmonary sarcomatoid carcinomafluorodeoxyglucosepositron emission tomography/computed tomographyimaging featuresTTF-1 expression |
| spellingShingle | Zhe-Huang Luo Xiao-Yan Luo Wan-Ling Qi Qian Liu 18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma Frontiers in Oncology pulmonary sarcomatoid carcinoma fluorodeoxyglucose positron emission tomography/computed tomography imaging features TTF-1 expression |
| title | 18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma |
| title_full | 18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma |
| title_fullStr | 18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma |
| title_full_unstemmed | 18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma |
| title_short | 18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma |
| title_sort | 18f fdg pet ct imaging in pulmonary sarcomatoid carcinoma |
| topic | pulmonary sarcomatoid carcinoma fluorodeoxyglucose positron emission tomography/computed tomography imaging features TTF-1 expression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1334156/full |
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