Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications
BackgroundContemporary advances in low-field magnetic resonance imaging systems can potentially widen access to cardiovascular magnetic resonance (CMR) imaging. We present our initial experience in building a comprehensive CMR protocol on a commercial 0.55 T system with a gradient performance of 26...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1120982/full |
| _version_ | 1811162582870917120 |
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| author | Juliet Varghese Ning Jin Daniel Giese Daniel Giese Chong Chen Yingmin Liu Yue Pan Nikita Nair Mahmoud T. Shalaan Mahmood Khan Mahmood Khan Matthew S. Tong Rizwan Ahmad Yuchi Han Yuchi Han Orlando P. Simonetti Orlando P. Simonetti Orlando P. Simonetti Orlando P. Simonetti |
| author_facet | Juliet Varghese Ning Jin Daniel Giese Daniel Giese Chong Chen Yingmin Liu Yue Pan Nikita Nair Mahmoud T. Shalaan Mahmood Khan Mahmood Khan Matthew S. Tong Rizwan Ahmad Yuchi Han Yuchi Han Orlando P. Simonetti Orlando P. Simonetti Orlando P. Simonetti Orlando P. Simonetti |
| author_sort | Juliet Varghese |
| collection | DOAJ |
| description | BackgroundContemporary advances in low-field magnetic resonance imaging systems can potentially widen access to cardiovascular magnetic resonance (CMR) imaging. We present our initial experience in building a comprehensive CMR protocol on a commercial 0.55 T system with a gradient performance of 26 mT/m amplitude and 45 T/m/s slew rate. To achieve sufficient image quality, we adapted standard imaging techniques when possible, and implemented compressed-sensing (CS) based techniques when needed in an effort to compensate for the inherently low signal-to-noise ratio at lower field strength.MethodsA prototype CMR exam was built on an 80 cm, ultra-wide bore commercial 0.55 T MR system. Implementation of all components aimed to overcome the inherently lower signal of low-field and the relatively longer echo and repetition times owing to the slower gradients. CS-based breath-held and real-time cine imaging was built utilizing high acceleration rates to meet nominal spatial and temporal resolution recommendations. Similarly, CS 2D phase-contrast cine was implemented for flow. Dark-blood turbo spin echo sequences with deep learning based denoising were implemented for morphology assessment. Magnetization-prepared single-shot myocardial mapping techniques incorporated additional source images. CS-based dynamic contrast-enhanced imaging was implemented for myocardial perfusion and 3D MR angiography. Non-contrast 3D MR angiography was built with electrocardiogram-triggered, navigator-gated magnetization-prepared methods. Late gadolinium enhanced (LGE) tissue characterization methods included breath-held segmented and free-breathing single-shot imaging with motion correction and averaging using an increased number of source images. Proof-of-concept was demonstrated through porcine infarct model, healthy volunteer, and patient scans.ResultsReasonable image quality was demonstrated for cardiovascular structure, function, flow, and LGE assessment. Low-field afforded utilization of higher flip angles for cine and MR angiography. CS-based techniques were able to overcome gradient speed limitations and meet spatial and temporal resolution recommendations with imaging times comparable to higher performance scanners. Tissue mapping and perfusion imaging require further development.ConclusionWe implemented cardiac applications demonstrating the potential for comprehensive CMR on a novel commercial 0.55 T system. Further development and validation studies are needed before this technology can be applied clinically. |
| first_indexed | 2024-04-10T06:31:50Z |
| format | Article |
| id | doaj.art-58caada204f644bc9500a869f55bb072 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T06:31:50Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-58caada204f644bc9500a869f55bb0722023-03-01T05:41:57ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11209821120982Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applicationsJuliet Varghese0Ning Jin1Daniel Giese2Daniel Giese3Chong Chen4Yingmin Liu5Yue Pan6Nikita Nair7Mahmoud T. Shalaan8Mahmood Khan9Mahmood Khan10Matthew S. Tong11Rizwan Ahmad12Yuchi Han13Yuchi Han14Orlando P. Simonetti15Orlando P. Simonetti16Orlando P. Simonetti17Orlando P. Simonetti18Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesCardiovascular MR R&D, Siemens Medical Solutions USA, Malvern, PA, United StatesMagnetic Resonance, Siemens Healthcare, Erlangen, GermanyInstitute of Radiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, GermanyDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United StatesDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United StatesDepartment of Emergency Medicine, The Ohio State University, Columbus, OH, United StatesDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, United StatesDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United StatesDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, United StatesDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United StatesDivision of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, United StatesDepartment of Radiology, The Ohio State University, Columbus, OH, United StatesBackgroundContemporary advances in low-field magnetic resonance imaging systems can potentially widen access to cardiovascular magnetic resonance (CMR) imaging. We present our initial experience in building a comprehensive CMR protocol on a commercial 0.55 T system with a gradient performance of 26 mT/m amplitude and 45 T/m/s slew rate. To achieve sufficient image quality, we adapted standard imaging techniques when possible, and implemented compressed-sensing (CS) based techniques when needed in an effort to compensate for the inherently low signal-to-noise ratio at lower field strength.MethodsA prototype CMR exam was built on an 80 cm, ultra-wide bore commercial 0.55 T MR system. Implementation of all components aimed to overcome the inherently lower signal of low-field and the relatively longer echo and repetition times owing to the slower gradients. CS-based breath-held and real-time cine imaging was built utilizing high acceleration rates to meet nominal spatial and temporal resolution recommendations. Similarly, CS 2D phase-contrast cine was implemented for flow. Dark-blood turbo spin echo sequences with deep learning based denoising were implemented for morphology assessment. Magnetization-prepared single-shot myocardial mapping techniques incorporated additional source images. CS-based dynamic contrast-enhanced imaging was implemented for myocardial perfusion and 3D MR angiography. Non-contrast 3D MR angiography was built with electrocardiogram-triggered, navigator-gated magnetization-prepared methods. Late gadolinium enhanced (LGE) tissue characterization methods included breath-held segmented and free-breathing single-shot imaging with motion correction and averaging using an increased number of source images. Proof-of-concept was demonstrated through porcine infarct model, healthy volunteer, and patient scans.ResultsReasonable image quality was demonstrated for cardiovascular structure, function, flow, and LGE assessment. Low-field afforded utilization of higher flip angles for cine and MR angiography. CS-based techniques were able to overcome gradient speed limitations and meet spatial and temporal resolution recommendations with imaging times comparable to higher performance scanners. Tissue mapping and perfusion imaging require further development.ConclusionWe implemented cardiac applications demonstrating the potential for comprehensive CMR on a novel commercial 0.55 T system. Further development and validation studies are needed before this technology can be applied clinically.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1120982/fullCMRlow-field0.55 TcineflowLGE |
| spellingShingle | Juliet Varghese Ning Jin Daniel Giese Daniel Giese Chong Chen Yingmin Liu Yue Pan Nikita Nair Mahmoud T. Shalaan Mahmood Khan Mahmood Khan Matthew S. Tong Rizwan Ahmad Yuchi Han Yuchi Han Orlando P. Simonetti Orlando P. Simonetti Orlando P. Simonetti Orlando P. Simonetti Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications Frontiers in Cardiovascular Medicine CMR low-field 0.55 T cine flow LGE |
| title | Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications |
| title_full | Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications |
| title_fullStr | Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications |
| title_full_unstemmed | Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications |
| title_short | Building a comprehensive cardiovascular magnetic resonance exam on a commercial 0.55 T system: A pictorial essay on potential applications |
| title_sort | building a comprehensive cardiovascular magnetic resonance exam on a commercial 0 55 t system a pictorial essay on potential applications |
| topic | CMR low-field 0.55 T cine flow LGE |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1120982/full |
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