Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings
It is desirable that noninvasive differential diagnosis takes place without lymph node biopsy for histiocytic necrotizing lymphadenitis (HNL) or malignant lymphoma (ML). In this study, we propose a novel scoring model for the differential diagnosis of these diseases using clinical information and cl...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/2/290 |
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| author | Taichi Omachi Naho Atsumi Takashi Yamazoe Sohsaku Yamanouchi Ryosuke Matsuno Tomoki Kitawaki Kazunari Kaneko |
| author_facet | Taichi Omachi Naho Atsumi Takashi Yamazoe Sohsaku Yamanouchi Ryosuke Matsuno Tomoki Kitawaki Kazunari Kaneko |
| author_sort | Taichi Omachi |
| collection | DOAJ |
| description | It is desirable that noninvasive differential diagnosis takes place without lymph node biopsy for histiocytic necrotizing lymphadenitis (HNL) or malignant lymphoma (ML). In this study, we propose a novel scoring model for the differential diagnosis of these diseases using clinical information and clinical findings. We retrospectively analyzed the data from 15 HNL and 13 ML pediatric patients. First, a univariate analysis identified 14 clinical factors with significant differences. Second, a subsequent analysis using receiver operating characteristic (ROC) curve analysis identified three factors among them with area under the ROC curve values of >0.95: body temperature (°C), maximum lymph node size (cm), and serum β<sub>2</sub>-microglobulin level (mg/L). Finally, the cut-off values of each of these three factors were determined and examined for the 28 cases. All 15 HNL cases were within 2–3 of the cut-off values among the three factors, no ML case was within two or more cut-off values. Thus, the diagnostic sensitivity and specificity of this novel scoring system were both 100%, indicating that clinical scoring with body temperature, maximum lymph node size, and β<sub>2</sub>-microglobulin are useful for distinguishing between HNL and ML. |
| first_indexed | 2024-03-09T22:17:12Z |
| format | Article |
| id | doaj.art-58cac90abccf42cca9eaccfc9728c9d9 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T22:17:12Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-58cac90abccf42cca9eaccfc9728c9d92023-11-23T19:20:38ZengMDPI AGChildren2227-90672022-02-019229010.3390/children9020290Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical FindingsTaichi Omachi0Naho Atsumi1Takashi Yamazoe2Sohsaku Yamanouchi3Ryosuke Matsuno4Tomoki Kitawaki5Kazunari Kaneko6Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanDepartment of Pathology, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanDepartment of Mathematics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanDepartment of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, JapanIt is desirable that noninvasive differential diagnosis takes place without lymph node biopsy for histiocytic necrotizing lymphadenitis (HNL) or malignant lymphoma (ML). In this study, we propose a novel scoring model for the differential diagnosis of these diseases using clinical information and clinical findings. We retrospectively analyzed the data from 15 HNL and 13 ML pediatric patients. First, a univariate analysis identified 14 clinical factors with significant differences. Second, a subsequent analysis using receiver operating characteristic (ROC) curve analysis identified three factors among them with area under the ROC curve values of >0.95: body temperature (°C), maximum lymph node size (cm), and serum β<sub>2</sub>-microglobulin level (mg/L). Finally, the cut-off values of each of these three factors were determined and examined for the 28 cases. All 15 HNL cases were within 2–3 of the cut-off values among the three factors, no ML case was within two or more cut-off values. Thus, the diagnostic sensitivity and specificity of this novel scoring system were both 100%, indicating that clinical scoring with body temperature, maximum lymph node size, and β<sub>2</sub>-microglobulin are useful for distinguishing between HNL and ML.https://www.mdpi.com/2227-9067/9/2/290lymphadenitisbody temperaturemaximum lymph node sizeβ<sub>2</sub>-microglobulin |
| spellingShingle | Taichi Omachi Naho Atsumi Takashi Yamazoe Sohsaku Yamanouchi Ryosuke Matsuno Tomoki Kitawaki Kazunari Kaneko Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings Children lymphadenitis body temperature maximum lymph node size β<sub>2</sub>-microglobulin |
| title | Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings |
| title_full | Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings |
| title_fullStr | Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings |
| title_full_unstemmed | Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings |
| title_short | Differential Diagnosis of Histiocytic Necrotizing Lymphadenitis and Malignant Lymphoma with Simple Clinical Findings |
| title_sort | differential diagnosis of histiocytic necrotizing lymphadenitis and malignant lymphoma with simple clinical findings |
| topic | lymphadenitis body temperature maximum lymph node size β<sub>2</sub>-microglobulin |
| url | https://www.mdpi.com/2227-9067/9/2/290 |
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