Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis
The integrity of skin tissue structure and function plays an important role in maintaining skin rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes skin aging through photodamage of the skin tissue. Cryptotanshinone (CTS), an active ingredient mianly derived from th...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1036013/full |
| _version_ | 1798030527743131648 |
|---|---|
| author | Keke Guo Run Liu Rongrong Jing Lusheng Wang Xuenan Li Kaini Zhang Mengli Fu Jiabin Ye Zhenlin Hu Wengang Zhao Nuo Xu |
| author_facet | Keke Guo Run Liu Rongrong Jing Lusheng Wang Xuenan Li Kaini Zhang Mengli Fu Jiabin Ye Zhenlin Hu Wengang Zhao Nuo Xu |
| author_sort | Keke Guo |
| collection | DOAJ |
| description | The integrity of skin tissue structure and function plays an important role in maintaining skin rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes skin aging through photodamage of the skin tissue. Cryptotanshinone (CTS), an active ingredient mianly derived from the Salvia plants of Lamiaceae, has many pharmacological effects, such as anti-inflammatory, antioxidant, and anti-tumor effects. In this study, we showed that CTS could ameliorate the photodamage induced by UV radiation in epidermal keratinocytes (HaCaT) and dermal fibroblasts (HFF-1) when applied to the cells before exposure to the radiation, effectively delaying the aging of the cells. CTS exerted its antiaging effect by reducing the level of reactive oxygen species (ROS) in the cells, attenuating DNA damage, activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, and reduced mitochondrial dysfunction as well as inhibiting apoptosis. Further, CTS could promote mitochondrial biosynthesis in skin cells by activating the AMP-activated protein kinase (AMPK)/sirtuin-1 (SIRT1)/peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) signaling pathway. These findings demonstrated the protective effects of CTS against UV radiation-induced skin photoaging and provided a theoretical and experimental basis for the application of CTS as an anti-photodamage and anti-aging agent for the skin. |
| first_indexed | 2024-04-11T19:42:41Z |
| format | Article |
| id | doaj.art-58cb3f32c56542d195daf2c746ecb5a5 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T19:42:41Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-58cb3f32c56542d195daf2c746ecb5a52022-12-22T04:06:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10360131036013Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosisKeke Guo0Run Liu1Rongrong Jing2Lusheng Wang3Xuenan Li4Kaini Zhang5Mengli Fu6Jiabin Ye7Zhenlin Hu8Wengang Zhao9Nuo Xu10College of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaZhiyuan College, Shanghai Jiao Tong University, Shanghai, ChinaCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaDepartment of Pharmacy, Zhoupu Hospital, Shanghai, ChinaCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaSchool of Medicine, Shanghai University, Shanghai, ChinaInstitute of Life Sciences, Wenzhou University, Wenzhou, ChinaCollege of Life and Environmental Sciences, Wenzhou University, Wenzhou, ChinaThe integrity of skin tissue structure and function plays an important role in maintaining skin rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes skin aging through photodamage of the skin tissue. Cryptotanshinone (CTS), an active ingredient mianly derived from the Salvia plants of Lamiaceae, has many pharmacological effects, such as anti-inflammatory, antioxidant, and anti-tumor effects. In this study, we showed that CTS could ameliorate the photodamage induced by UV radiation in epidermal keratinocytes (HaCaT) and dermal fibroblasts (HFF-1) when applied to the cells before exposure to the radiation, effectively delaying the aging of the cells. CTS exerted its antiaging effect by reducing the level of reactive oxygen species (ROS) in the cells, attenuating DNA damage, activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, and reduced mitochondrial dysfunction as well as inhibiting apoptosis. Further, CTS could promote mitochondrial biosynthesis in skin cells by activating the AMP-activated protein kinase (AMPK)/sirtuin-1 (SIRT1)/peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) signaling pathway. These findings demonstrated the protective effects of CTS against UV radiation-induced skin photoaging and provided a theoretical and experimental basis for the application of CTS as an anti-photodamage and anti-aging agent for the skin.https://www.frontiersin.org/articles/10.3389/fphar.2022.1036013/fullcryptotanshinone (CTS)ultraviolet (UV) radiationphotoagingoxidative stressmitochondrial dysfunctionapoptosis |
| spellingShingle | Keke Guo Run Liu Rongrong Jing Lusheng Wang Xuenan Li Kaini Zhang Mengli Fu Jiabin Ye Zhenlin Hu Wengang Zhao Nuo Xu Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis Frontiers in Pharmacology cryptotanshinone (CTS) ultraviolet (UV) radiation photoaging oxidative stress mitochondrial dysfunction apoptosis |
| title | Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis |
| title_full | Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis |
| title_fullStr | Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis |
| title_full_unstemmed | Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis |
| title_short | Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis |
| title_sort | cryptotanshinone protects skin cells from ultraviolet radiation induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis |
| topic | cryptotanshinone (CTS) ultraviolet (UV) radiation photoaging oxidative stress mitochondrial dysfunction apoptosis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1036013/full |
| work_keys_str_mv | AT kekeguo cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT runliu cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT rongrongjing cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT lushengwang cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT xuenanli cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT kainizhang cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT menglifu cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT jiabinye cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT zhenlinhu cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT wengangzhao cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis AT nuoxu cryptotanshinoneprotectsskincellsfromultravioletradiationinducedphotoagingviaitsantioxidanteffectandbyreducingmitochondrialdysfunctionandinhibitingapoptosis |