Improvement of spinal cord injury symptoms by targeting the Bax/Bcl2 pathway and modulating TNF-α/IL-10 using Platelet-Rich Plasma exosomes loaded with dexamethasone

Improvement of spinal cord injury symptoms by targeting the Bax/Bcl2 pathway and modulating TNF-α/IL-10 using Platelet-Rich Plasma exosomes loaded with dexamethasone

Spinal cord injury (SCI) is a debilitating condition that results in impaired sensory and motor function due to the limited self-regenerative ability of the spinal cord. To address this issue, combination therapy has been proposed as an effective treatment strategy for SCI regeneration. In this stud...

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Bibliographic Details
Main Authors: Naeimeh Akbari-Gharalari, Maryam Ghahremani-Nasab, Roya Naderi, Zeinab Aliyari-Serej, Mohammad Karimipour, Parviz Shahabi, Abbas Ebrahimi-Kalan
Format: Article
Language:English
Published: AIMS Press 2023-11-01
Series:AIMS Neuroscience
Subjects:
spinal cord injury
prp-derived exosome
dexamethasone
drug delivery
signaling pathways
Online Access:https://www.aimspress.com/article/doi/10.3934/Neuroscience.2023026?viewType=HTML

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