Epidermal RAF prevents allergic skin disease

Epidermal RAF prevents allergic skin disease

The RAS pathway is central to epidermal homeostasis, and its activation in tumors or in Rasopathies correlates with hyperproliferation. Downstream of RAS, RAF kinases are actionable targets regulating keratinocyte turnover; however, chemical RAF inhibitors paradoxically activate the pathway, promoti...

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Bibliographic Details
Main Authors: Josipa Raguz, Ines Jeric, Theodora Niault, Joanna Daniela Nowacka, Sanya Eduarda Kuzet, Christian Rupp, Irmgard Fischer, Silvia Biggi, Tiziana Borsello, Manuela Baccarini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
mechanisms of disease
allergy
atopic dermatitis
RAF
MAPK
Online Access:https://elifesciences.org/articles/14012

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